Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2019, Article ID 8983903, 10 pages
https://doi.org/10.1155/2019/8983903
Research Article

Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients

1Laboratory of Cellular Immunity, Institute of Clinical Immunology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, China
2The Pennington School, 112 W Delaware Ave, Pennington, NJ 08534, USA
3Department of Hepatopathy, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Correspondence should be addressed to Man Li; moc.621@000121namil

Received 29 June 2018; Accepted 3 October 2018; Published 13 January 2019

Guest Editor: YinYing Lu

Copyright © 2019 Long-Shan Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. GBD 2013 Mortality and Causes of Death Collaborators, “Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the global burden of disease Study 2013,” The Lancet, vol. 385, no. 9963, pp. 117–171, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Zou, W. Zhang, and S. Ruan, “Modeling the transmission dynamics and control of hepatitis B virus in China,” Journal of Theoretical Biology, vol. 262, no. 2, pp. 330–338, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. D. Jia and H. Zhuang, “The overview of the seminar on chronic hepatitis B,” Zhonghua gan zang bing za zhi= Zhonghua ganzangbing zazhi= Chinese journal of hepatology, vol. 12, no. 11, pp. 698-699, 2004. View at Google Scholar
  4. S. T. Goldstein, F. Zhou, S. C. Hadler, B. P. Bell, E. E. Mast, and H. S. Margolis, “A mathematical model to estimate global hepatitis B disease burden and vaccination impact,” International Journal of Epidemiology, vol. 34, no. 6, pp. 1329–1339, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. S. F. Lok and B. J. McMahon, “Chronic hepatitis B: update 2009,” Hepatology, vol. 50, no. 3, pp. 661-662, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. European Association for the Study of the Liver, “EASL clinical practice guidelines: management of chronic hepatitis B virus infection,” Journal of Hepatology, vol. 57, no. 1, pp. 167–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. K. Maini and A. J. Gehring, “The role of innate immunity in the immunopathology and treatment of HBV infection,” Journal of Hepatology, vol. 64, no. 1, pp. S60–S70, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Bertoletti and C. Ferrari, “Adaptive immunity in HBV infection,” Journal of Hepatology, vol. 64, no. 1, pp. S71–S83, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Ducheix, A. Montagner, A. Polizzi et al., “Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor,” Journal of Hepatology, vol. 58, no. 5, pp. 984–992, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Yamamoto, T. Tatsumi, T. Miyagi et al., “α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells,” Clinical and Experimental Immunology, vol. 165, no. 2, pp. 211–219, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. H. Aalaei-Andabili and S. M. Alavian, “Regulatory T cells are the most important determinant factor of hepatitis B infection prognosis: a systematic review and meta-analysis,” Vaccine, vol. 30, no. 38, pp. 5595–5602, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Feng, J. Yin, Y. P. Han et al., “Regulatory T cells and IL-17(+) T helper cells enhanced in patients with chronic hepatitis B virus infection,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 6, pp. 8674–8685, 2015. View at Google Scholar
  13. E. Chan, M. Tan, J. Xin, S. Sudarsanam, and D. E. Johnson, “Interactions between traditional Chinese medicines and Western therapeutics,” Current Opinion in Drug Discovery & Development, vol. 13, no. 1, pp. 50–65, 2010. View at Google Scholar
  14. W. Dai, C. Wei, H. Kong et al., “Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 56, no. 1, pp. 86–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. An, S. Gao, D. Cheng et al., “Peginterferon and Chinese herbs exert a combinatorial effect in HBeAg-positive chronic hepatitis B,” Journal of Infection in Developing Countries, vol. 10, no. 04, pp. 369–376, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Li, X. H. Sun, Z. H. Zhou et al., “Beneficial therapeutic effect of Chinese herbal Bushen formula on CHB patients with mildly elevated alanine aminotransferase by down-regulating CD4+CD25+ T cells,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 614–622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Infectious Diseases, Chinese Medical Association, J. L. Hou, and W. Lai, “The guideline of prevention and treatment for chronic hepatitis B: a 2015 update,” Zhonghua gan zang bing za zhi= Zhonghua ganzangbing zazhi= Chinese journal of hepatology, vol. 23, no. 12, pp. 888–905, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Li, Z. H. Zhou, X. H. Sun et al., “The dynamic changes of circulating invariant natural killer T cells during chronic hepatitis B virus infection,” Hepatology International, vol. 10, no. 4, pp. 594–601, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Baran, D. Kowalczyk, M. Ozog, and M. Zembala, “Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation,” Clinical and Diagnostic Laboratory Immunology, vol. 8, no. 2, pp. 303–313, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. X. J. Zhu, X. H. Sun, Z. H. Zhou et al., “Lingmao formula combined with entecavir for HBeAg-positive chronic hepatitis B patients with mildly elevated alanine aminotransferase: a multicenter, randomized, double-blind, placebo-controlled trial,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 620230, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Liu, P. Liu, R. Dai et al., “Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B,” Journal of Pharmaceutical and Biomedical Analysis, vol. 59, pp. 173–178, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Chen, X. Ma, Y. Zhao et al., “Kushenin combined with nucleos(t)ide analogues for chronic hepatitis B: a systematic review and meta-analysis,” Evidence-based Complementary and Alternative Medicine, vol. 2015, Article ID 529636, 12 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Li, Z. Ye, X. Gao et al., “Diwu Yanggan capsule improving liver histological response for patients with HBeAg-negative chronic hepatitis B: a randomized controlled clinical trial,” American Journal of Translational Research, vol. 10, no. 5, pp. 1511–1521, 2018. View at Google Scholar
  24. Q. Y. Liu, Y. M. Yao, Y. Yu, N. Dong, and Z. Y. Sheng, “Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25 (high) T cells,” PLoS One, vol. 6, no. 6, article e19811, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. H. Chen, X. F. Wu, J. Hao, M. L. Chen, and G. Y. Zhu, “Selection and purification potential evaluation of woody plant in vertical flow constructed wetlands in the subtropical area,” Huan Jing Ke Xue, vol. 35, no. 2, pp. 585–591, 2014. View at Google Scholar