MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Figure 2

Decreased MPC1 enhances tumor metastasis and predicts poor prognosis in CRC. (a, b) Data mining showed MPC1 expression was gradually decreased in normal tissue, primary CRC, and liver lesion of metastatic CRC (M-CRC) from two independent GEO datasets (One-way ANOVA, A, GSE21510, ; B, GSE89393, ). (c) Data from GSE67675 revealed that MPC1 expression was lower in high liver metastasis CT26 cells (HM-CT26) than that in poor liver metastasis CT26 cells (PM-CT26) (Student’s -test, ). (d) Gradually decreased MPC1 expression was presented in normal tissue, primary CRC, and liver metastasis CRC (CRLM) tissue (Scale bar: 200 μm) (, Fisher’s exact test, ). (e) Kaplan-Meier overall survival (OS) curves in the TCGA dataset of CRC patients according to the mRNA expression of MPC1, the lower quartile value of expression was utilized as a cut-off (log-rank test, ). (f) Kaplan-Meier OS curve for the MPC1 expression in the Ren Ji cohort (log-rank test, ). (g) Kaplan-Meier OS curve for the MPC1 expression in patients with metastasis (log-rank test, ). (h) Kaplan-Meier OS curve for the MPC1 expression in patients without metastasis (log-rank test, ).

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