Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2-Based Protein for Human Visceral Leishmaniasis Diagnosis

Table 4

Performance of DTL-4-ELISA to diagnosis of VL in samples of AIDS patients from different locations in Brazil.

Location	Subjects	Diagnostic accuracy (95% CI)
		Sensitivity% (); 95% CI	Specificity% (); 95% CI	Accuracy%; 95% CI
Campo Grande (Mato Grosso do Sul state)	VL	97.26 (73); 89.98-99.82	—	98.84; 95.61-99.95
	VL/AIDS	81.82 (44); 67.78-90.75	—	94.44; 89.26-97.32
	Healthy		100.00 (121); 96.30-100.00	—
Bauru (São Paulo state)	VL	100.00 (12); 71.80-100.00	—	100.00; 80.21-100.00
	VL/AIDS	100.00 (04); 45.41-100.00	—	100.00; 69.98-100.00
	Healthy		100.00 (07); 59.56-100.00	—
Total	VL	97.65 (85); 91.32-99.86	—	99.06; 96.42-99.97
	VL/AIDS	83.33 (48); 70.16-91.57	—	95.48; 91.20-97.83
	Healthy		100.00 (128); 96.50-100.00	—

VL: visceral leishmaniasis; VL/AIDS: coinfection; healthy donors; : number of samples; 95% CI: 95% confidence interval.