Comparison of Instantaneous Wave-Free Ratio (iFR) and Fractional Flow Reserve (FFR) with respect to Their Sensitivities to Cardiovascular Factors: A Computational Model-Based Study

Table 2

Reference values of model parameters involved in the sensitivity analyses for iFR and FFR under resting and hyperemic conditions.

Model parameter	Reference value (resting/hyperemic)	Range of variation (resting)
EOAdia (cm^2)	0.0/0.0	(0.0∼0.3) [27]
EOAsys (cm^2)	4.0/4.0	(4.0∼1.0) [28, 29]
Elva (mmHg/ml)	2.87/2.87	(1.435∼6.601) [30]
Elvb (mmHg/ml)	0.056/0.056	(0.028∼0.112) [30]
HR (beats/min)	66/90	(48∼111) [31, 32]
aPWV (m/s)	4.7/4.7	(3.478∼10.011) [33–35]
Rsys (mmHg·s/ml)	1.14/0.98	(0.456∼1.824) [36, 37]
Rcmv (mmHg·s/ml)	196.97/45.94	(157.58∼433.33) [38–40]

Note that the ranges of parameter variations under resting condition were estimated based on available clinical data reported in the literature.