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Journal of Nanomaterials
Volume 2010, Article ID 232017, 8 pages
Research Article

Electrospun Poly(L-Lactide-co-ε-Caprolactone)/Polyethylene Oxide/Hydroxyapaite Nanofibrous Membrane for Guided Bone Regeneration

1Institute of Nano and Bio-Polymeric Material, School of Material Science and Engineering, Tongji University, Shanghai, 200092, China
2School of Stomatology, Tongji University, Shanghai, 200092, China

Received 28 September 2009; Revised 22 November 2009; Accepted 5 March 2010

Academic Editor: Huisheng Peng

Copyright © 2010 Gang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of poly(L-lactide-co- -caprolactone)/polyethylene oxide/hydroxyapaite (PLCL/PEO/HA) composite fibrous membranes were prepared by elecrospinning technology for guided bone regeneration. The morphology, water permeability and mechanical properties of the membranes were investigated. The HA nanocrystals can be well distributed in the PLCL/PEO matrix. And the diameter of composite nanofiber is larger than that of pure PLCL. The fibers with uniform size and large diameter were obtained when the contents of PEO and HA were 0.4% and 0.03%, respectively. In this condition, the obtained membrane presents the best water permeability. Furthermore, the nanofibrous membrane with largest tensile strength was obtained when the contents of PEO and HA were 0.5% and 0.03%, respectively.