Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates

Table 2

Microscopic characteristics of HA-DOCA self-aggregates determined by the fluorescence probe method.

sample	CAC^a (mg/mL)	𝐾𝑣b (×10^4)	𝑁cDOCA	𝑁dchain
HD6	0.056	1.45	17.6	2.98
HD7	0.037	2.83	27.8	3.66
HD9	0.025	3.64	43	4.57

^aCritical aggregation concentration determined by pyrene emission spectra. ^bBinding equilibrium constant for pyrene in distilled water in the presence of HA-DOCA nanoparticles. ^cAggregation number of DOCA moieties per one hydrophobic domain. ^dNumber of HA-DOCA conjugate polymer chains per one hydrophobic domain.