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Journal of Nanomaterials
Volume 2013 (2013), Article ID 681391, 6 pages
Research Article

Hierarchical Structures and Shaped Particles of Bioactive Glass and Its In Vitro Bioactivity

1Molecular Technology Research Unit, School of Science, Walailak University, Nakhon Si Thammarat 80161, Thailand
2Department of Chemistry, University of Minnesota, MN 55455, USA

Received 12 April 2013; Revised 3 June 2013; Accepted 22 July 2013

Academic Editor: Jie Huang

Copyright © 2013 U. Boonyang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this study, bioactive glass particles with controllable structure and porosity were prepared using dual-templating methods. Block copolymers used as one template component produced mesopores in the calcined samples. Polymer colloidal crystals as the other template component yielded either three-dimensionally ordered macroporous (3DOM) products or shaped bioactive glass nanoparticles. The in vitro bioactivity of these bioactive glasses was studied by soaking the samples in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time and monitoring the formation of bone-like apatite on the surface of the bioactive glass. A considerable bioactivity was found that all of bioactive glass samples have the ability to induce the formation of an apatite layer on its surface when in contact with SBF. The development of bone-like apatite is faster for 3DOM bioactive glasses than for nanoparticles.