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Journal of Nanomaterials
Volume 2013, Article ID 762381, 9 pages
Research Article

Preparation and In Vitro and In Vivo Performance of Magnesium Ion Substituted Biphasic Calcium Phosphate Spherical Microscaffolds as Human Adipose Tissue-Derived Mesenchymal Stem Cell Microcarriers

1School of Materials Science and Engineering, Pusan National University, Busan 609-735, Republic of Korea
2Korea Institutes of Industrial Technology, Busan 618-230, Republic of Korea
3Department of Physiology, School of Medicine, Pusan National University, Yangsan 626-770, Republic of Korea
4School of Nano and Advanced Materials, Gyeongsang National University, Jinju 660-701, Republic of Korea
5Department of Advanced Materials Engineering, Chosun University, Gwangju 501-759, Republic of Korea

Received 17 April 2013; Accepted 16 May 2013

Academic Editor: Eng San Thian

Copyright © 2013 Dong-Hyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Magnesium ion substituted biphasic calcium phosphate (Mg-BCP) bioceramic microscaffolds with spherical and porous morphology were successfully prepared using in situ coprecipitation and rotary spray drying atomization process for application of tissue engineering combined with human adipose tissue-derived mesenchymal stem cells (hAT-MSCs). After 4 weeks of immersion in Hanks’ balanced salt solution (HBSS), Mg-BCP micro-scaffolds showed the enhanced biodegradation and bioactivity due to the substituted Mg2+ ion present in the BCP structure. In this study, it was observed that hAT-MSCs have clearly attached on the surface of Mg-BCP micro-scaffolds. In addition, Mg-BCP micro-scaffolds exhibited the improved biocompatibility and osteoconductivity via in vitro and in vivo biological tests with hAT-MSCs. Therefore, these bioceramic micro-scaffolds had potential to be used as hAT-MSCs microcarriers for biomedical applications.