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Journal of Nanomaterials
Volume 2013, Article ID 802318, 7 pages
Research Article

Visible Light Irradiation-Mediated Drug Elution Activity of Nitrogen-Doped TiO2 Nanotubes

1Department of Dental Biomaterials and Institute of Biomaterial and Implant, College of Dentistry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea
2Department of Dentistry, College of Dentistry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea
3Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093, USA

Received 19 October 2012; Revised 23 December 2012; Accepted 24 December 2012

Academic Editor: Fengqiang Sun

Copyright © 2013 Seunghan Oh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have developed nitrogen-doped nanotubes showing photocatalytic activity in the visible light region and have investigated the triggered release of antibiotics from these nanotubes in response to remote visible light irradiation. Scanning electron microscopy (SEM) observations indicated that the structure of nanotubes was not destroyed on the conditions of 0.05 and 0.1 M diethanolamine treatment. The results of X-ray photoelectron spectroscopy (XPS) confirmed that nitrogen, in the forms of nitrite ( ) and nitrogen monoxide (NO), had been incorporated into the nanotube surface. A drug-release test revealed that the antibiotic-loaded nanotubes showed sustained and prolonged drug elution with the help of polylactic acid. Visible light irradiation tests showed that the antibiotic release from nitrogen-doped nanotubes was significantly higher than that from pure nanotubes ( ).