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Journal of Nanomaterials
Volume 2014 (2014), Article ID 573238, 6 pages
http://dx.doi.org/10.1155/2014/573238
Research Article

Bioactivity Assessment of Poly(ɛ-caprolactone)/Hydroxyapatite Electrospun Fibers for Bone Tissue Engineering Application

Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), Skudai, 81310 Johor Bahru, Johor, Malaysia

Received 9 May 2014; Accepted 26 June 2014; Published 9 July 2014

Academic Editor: Hao Bai

Copyright © 2014 Mohd Izzat Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Electrospinning is useful for fabricating nanofibrous structure with different composition and morphologies. It offers great advantages through its geometrical structure and biomimetic property, which can provide a suitable environmental site for cell growth. The fiber diameter is entangled by the concentration of PCL with some adjustment of parameters during electrospinning process. PCL with lower concentration had bead structure while higher concentration had smooth fiber. The incorporation of nanoparticle hydroxyapatite (nHA) into poly(ɛ-caprolactone) fiber was studied. The fiber diameter of PCL was increased with the addition of nHA. Composition of fiber at lower concentrations of PCL and nHA into the polymer produced fiber with a homogenous distribution of nHA in PCL fiber with less agglomeration. The immersion of PCL/nHA fiber in simulated body fluid (SBF) had bone-like apatite layer on its surface while PCL showed no results. PCL/nHA showed high water uptake and had improved wettability compared to PCL alone, suggesting that PCL/nHA fibers were more hydrophilic than PCL fiber.