UV Photocatalysis of Bone Marrow-Derived Macrophages on TiO₂ Nanotubes Mediates Intracellular Ca²⁺ Influx via Voltage-Gated Ca²⁺ Channels

Figure 3

Nicardipine, an inhibitor of voltage-gated Ca²⁺ channel, attenuates UV photocatalysis-mediated increase but not reduction. Isolated BMMs were seeded on polished Ti and TiO₂ nanotubes and loaded with Fura-2/AM and CM-H2DCFDA. (a) UV photocatalysis-mediated increase in cells on TiO₂ nanotubes was measured in the presence of nicardipine (10 μM) diluted in HEPES buffer. (b, c) The columns indicate increment and decrement in BMMs.

(a)

(b)

(c)