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Journal of Nanomaterials
Volume 2017, Article ID 1047697, 7 pages
https://doi.org/10.1155/2017/1047697
Research Article

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

1National Institute for Materials Science, Sengen 1-2-1, Tsukuba 305-0047, Japan
2University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
3The University of Shiga Prefecture, Hikone 522-8533, Japan

Correspondence should be addressed to Hiroaki Mamiya; pj.og.smin@ikaorih.ayimam

Received 21 June 2017; Accepted 20 November 2017; Published 13 December 2017

Academic Editor: Mohammad Mansoob Khan

Copyright © 2017 Hiroaki Mamiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency of 25 kHz. The limit corresponds to the value of 2.5 × 106 Oe·s−1 and is significantly lower than the conventionally accepted criteria of 6 × 107 Oe·s−1. The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.