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Journal of Nanomaterials
Volume 2017, Article ID 4852190, 8 pages
Research Article

Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration

1Basic Sciences Laboratory, Faculty of Stomatology, San Luis Potosi University, San Luis Potosi, SLP, Mexico
2Tissue Bioengineering Laboratory, Postgraduate and Research Division Studies, Faculty of Dentistry, National University of Mexico, Mexico City, Mexico
3Interfacultary Research Center of Biomaterials, Institute of Chemistry, University of Liège, Liège, Belgium

Correspondence should be addressed to H├ęctor Flores; xm.plsau@serolfeh

Received 25 May 2017; Revised 9 October 2017; Accepted 23 October 2017; Published 20 November 2017

Academic Editor: Samuel M. Mugo

Copyright © 2017 Mariné Ortiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The new era of biomaterials for repairing bone tissue injury continues to be a challenge in bone tissue engineering. The fiber scaffolds allow for cellular interconnection and a microenvironment close to the bone extracellular matrix. The aim of this study was to evaluate the osteoblast behavior on a 3D textile of PGA (polyglycolic acid) fibers functionalized with the RGD (R: arginine; G: glycine; D: aspartic acid) peptide. The cell morphology, proliferation, and calcium phosphate deposition ability were evaluated on textiles at different time intervals under a confocal laser scanning microscope. The osteoblast viability ranged from 92% to 98%, and cell proliferation was higher in PGA-RGD than control PGA (uncoated). In addition, the osteoblast calcium phosphate deposition was significantly greater on PGA-RGD in osteogenic inductor medium (OIM) in contrast to controls without inducing factors. The PGA-RGD fibers supported proliferation and viability of osteoblast and stimulated bone osteogenesis and mineralization. These results support the adoption of this 3D polymeric textile as a scaffold for bone tissue engineering.