Efficient Delivery of Therapeutic siRNA with Nanoparticles Induces Apoptosis in Prostate Cancer Cells

Figure 6

Systemic delivery of PEG-LP/siJnk-1 NPs suppressed the growth of DU145 xenografts in nude mice. (a) Relative tumor volume of nude mice bearing DU145 tumors treated with PBS, PEG-LP NPs, PEG-LP/siN.C. NPs, or PEG-LP/siJnk-1 NPs. Data are presented as the means ± SD. (b) TUNEL assays of tumor tissues after treatment with the various formulations. (c) Hematoxylin and eosin (HE) staining of organs, including heart, liver, spleen, lung, and kidney from mice treated with the various formulations.

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