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Journal of Nanomaterials
Volume 2018 (2018), Article ID 6274072, 8 pages
https://doi.org/10.1155/2018/6274072
Research Article

Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification

1School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
2Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, PA 19104, USA
3Chemistry Division, U.S. Naval Research Laboratory, Washington, DC 20375, USA
4Department of Chemistry and Department of Materials Science & Engineering, Missouri University of Science & Technology, Rolla, MO 65409, USA

Correspondence should be addressed to Susan Sandeman; ku.ca.nothgirb@namednas.s

Received 19 July 2017; Revised 11 January 2018; Accepted 22 January 2018; Published 21 February 2018

Academic Editor: Renyun Zhang

Copyright © 2018 Yishan Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction. Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion. In this study, we explore the use of graphene nanoplatelets (GNP) as low-cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers. Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed. The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2. GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethylene) film with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.