The field of nanoscience and technology has grown exponentially in recent years and has expanded its footprint in various fields. Nanomaterials and nanoengineered systems offer an array of exciting opportunities in healthcare, particularly in the field of tissue engineering. For instance, electrospun scaffolds have attracted a great deal of attention from the tissue engineering community, owing to their high surface to volume ratio. Several such nanoscale materials have been made into bioactive composites by incorporating moieties that impart characteristics such as electrical conductivity or antimicrobial properties. Some of these nanomaterials have been transformed into nanoengineered systems, such as nerve guidance conduits or vascular grafts. Recently, nanomaterials are being explored alongside another fascinating field, 3D printing and bioprinting, to generate next-generation tissue engineering scaffolds.

Clearly, the field is evolving and many more innovative nanomaterials and nanoengineered systems are going to emerge and expand the horizons of the tissue engineering field. Yet, there are quite a few challenges in the field. For instance, although there are various approaches in the literature, there is a lack of adequate green, sustainable, and smart approaches for the synthesis and functionalisation of nanomaterials. Most of the studies also lack adequate insights into the fundamental understanding of the process, structure, and property relationship of nanomaterials. Particularly, in the field of tissue engineering, understanding cell or stem cell–material interactions is of prime importance, however, there is still no consensus on how nano-scale features affect cellular behaviour. Nanomaterials are now being explored in the field of 3D printing and bioprinting, however, how nanomaterials would benefit from this interesting relationship is not fully known. There is also scope for further investigations on pre-clinical performance evaluation studies to understand cell and tissue response. Lastly, there is a tremendous need to bring harmonized guidelines on safety and regulatory aspects in the field.

This Special Issue, therefore, aims to provide comprehensive and state-of-the-art coverage on various aspects of nanomaterials and nanoengineered systems in the fabrication of artificial tissues. We invite authors from across the globe working in the exciting field of nano-tissue engineering to share their experience, and both original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Synthesis/ processing of nano-tissue engineering materials or systems, including green or sustainable practices
• Characterisation studies, including process–structure–property–function relationship investigations, in the context of tissue engineering
• Functionalisation strategies, including bio-, stimuli responsive-, smart- and multi-functionalisation approaches, in the context of tissue engineering
• Cell and stem cell–material interaction studies, including mechano-biology aspects
• Cross-disciplinary nano-tissue engineering approaches, including 3D printing and bioprinting
• Applications across various fields of tissue engineering, including in vitro and in vivo performance evaluation studies
• Safety and regulatory aspects in nano-tissue engineering materials or systems