The skin is considered an important drug delivery route for local or systemic effects. However, skin barriers can make topical delivery of therapeutic compounds challenging since only a few drugs possess the ideal characteristics to penetrate across the stratum corneum and reach the target site. Due to their unique structure and chemical characteristics, nanomaterials are being investigated as potential carriers for site-specific drug delivery. Research in the era of nanomaterials has led to renewed interest in the topical delivery of therapeutic agents. Over the past ten years, the use of nanomaterials and nanotechnology in several disciplines of medicine and cosmeceuticals has increased. Nanotechnology served as a promising approach to overcome and tackle the challenges associated with the healthcare sector. In addition, cosmetics are one of the first sectors in which the concept of nanotechnology was applied. In recent years, it has been observed that the use of nanotechnology in the cosmetics industry is booming day by day. Nanomaterials' particle size, shape, charge, and other surface features have a considerable impact on cellular uptake, diffusion, and drug release.

There are, however, several challenges in developing nanomaterials to meet regulatory guidelines. Nanomaterials and nanocosmetics require strong regulatory guidelines since they can show harmful effects due to skin sensitization. Particle size greatly impacts the toxicity profile of the nanoformulation, hence it becomes crucial to characterize nano-formulations.

The aim of this Special Issue is to encourage manuscripts highlighting nanomaterials for topical drug delivery in certain areas. We hope to bring together researchers, scientists, and academicians working in the recent eras of nanomaterials. Original research and review articles pertaining to the scope of this Special Issue are welcome.

Potential topics include but are not limited to the following:

• Fabrication of nanomaterials for topical drug delivery and theranostic purpose
• Designing of novel topical drug delivery systems for management of:Wound (burns and accidental injuries, tissue repair and regeneration); Psoriasis, Eczema and Pruritus; Antiaging/Anti-acne/Anti-wrinkle; Skin cancer; and Skin infection
• Development of topical nano-cosmeceuticals
• Nanofibres, nano-sponges and other nano-composites
• Nanocarrier systems for topical delivery of micronutrients.