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Journal of Oncology
Volume 2009 (2009), Article ID 963209, 12 pages
http://dx.doi.org/10.1155/2009/963209
Review Article

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

1Center for Cell Biology & Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
2Department of Pathology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
3Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer, University of Liège, Avenue de l'Hôpital 3, 4000 Liège, Belgium

Received 26 August 2009; Accepted 24 November 2009

Academic Editor: Guus A. M. S. Van Dongen

Copyright © 2009 Jennifer Freytag et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Rohan Samarakoon, Jessica M. Overstreet, Stephen P. Higgins, and Paul J. Higgins, “TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis,” Cell and Tissue Research, vol. 347, no. 1, pp. 117–128, 2011. View at Publisher · View at Google Scholar
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  • Stephen P. Higgins, Craig E. Higgins, and Paul J. Higgins, “PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells,” International Journal of Cell Biology, vol. 2011, pp. 1–8, 2011. View at Publisher · View at Google Scholar
  • Jelena Kocic, Diana Bugarski, and Juan F. Santibanez, “SMAD3 is essential for transforming growth factor-beta 1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes,” European Journal Of Cancer, vol. 48, no. 10, pp. 1550–1557, 2012. View at Publisher · View at Google Scholar
  • R. Matthew Klein, Daniel Bernstein, Steven P. Higgins, Craig E. Higgins, and Paul J. Higgins, “SERPINE1 expression discriminates site-specific metastasis in human melanoma,” Experimental Dermatology, vol. 21, no. 7, pp. 551–554, 2012. View at Publisher · View at Google Scholar
  • Xiaoling Song, Frederic W. Thalacker, and Marit Nilsen-Hamilton, “Synergistic and Multidimensional Regulation of Plasminogen Activator Inhibitor Type 1 Expression by Transforming Growth Factor Type beta and Epidermal Growth Factor,” Journal Of Biological Chemistry, vol. 287, no. 15, pp. 12520–12528, 2012. View at Publisher · View at Google Scholar
  • Cynthia E. Wilkins-Port, Stephen P. Higgins, Craig E. Higgins, Issey Kobori-Hotchkiss, and Paul J. Higgins, “Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades,” Biochemistry Research International, vol. 2012, pp. 1–8, 2012. View at Publisher · View at Google Scholar
  • Rohan Samarakoon, Jessica M. Overstreet, and Paul J. Higgins, “TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities,” Cellular Signalling, vol. 25, no. 1, pp. 264–268, 2013. View at Publisher · View at Google Scholar
  • Ge Zhang, Makito Miyake, Adrienne Lawton, Steve Goodison, and Charles J. Rosser, “Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors,” Bmc Cancer, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann, and Verena Dexheimer, “Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications,” Stem Cell Research & Therapy, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Tessa M. Simone, Craig E. Higgins, Ralf-Peter Czekay, Brian K. Law, Stephen P. Higgins, Jaclyn Archambeault, Stacie M. Kutz, and Paul J. Higgins, “SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-“Activated” Keratinocytes,” Advances in Wound Care, vol. 3, no. 3, pp. 281–290, 2014. View at Publisher · View at Google Scholar
  • Christophe Desterke, Christophe Martinaud, Nadira Ruzehaji, and Marie-Caroline Le Bousse-Kerdilès, “Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis,” Mediators of Inflammation, vol. 2015, pp. 1–16, 2015. View at Publisher · View at Google Scholar
  • Girdhari Rijal, and Weimin Li, “3D scaffolds in breast cancer research,” Biomaterials, vol. 81, pp. 135–156, 2016. View at Publisher · View at Google Scholar
  • Stephen P. Higgins, Yi Tang, Craig E. Higgins, Badar Mian, Wenzheng Zhang, Ralf-Peter Czekay, Rohan Samarakoon, David J. Conti, and Paul J. Higgins, “TGF-β1/p53 signaling in renal fibrogenesis,” Cellular Signalling, 2017. View at Publisher · View at Google Scholar