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Journal of Oncology
Volume 2010, Article ID 932371, 13 pages
http://dx.doi.org/10.1155/2010/932371
Review Article

Ovarian Cancer Pathogenesis: A Model in Evolution

1Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
2Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Received 1 June 2009; Accepted 23 June 2009

Academic Editor: Tian-Li Wang

Copyright © 2010 Alison M. Karst and Ronny Drapkin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [128 citations]

The following is the list of published articles that have cited the current article.

  • M. G. M. Braem, N. C. Onland-Moret, P. A. van den Brandt, R. A. Goldbohm, P. H. M. Peeters, R. F. P. M. Kruitwagen, and L. J. Schouten, “Reproductive and Hormonal Factors in Association With Ovarian Cancer in the Netherlands Cohort Study,” American Journal of Epidemiology, vol. 172, no. 10, pp. 1181–1189, 2010. View at Publisher · View at Google Scholar
  • C. Van Holsbeke, V. Van Belle, F. P. G. Leone, S. Guerriero, D. Paladini, G. B. Melis, S. Greggi, D. Fischerova, E. De Jonge, P. Neven, T. Bourne, L. Valentin, S. Van Huffel, and D. Timmerman, “Prospective external validation of the 'ovarian crescent sign' as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology,” Ultrasound In Obstetrics & Gynecology, vol. 36, no. 1, pp. 81–87, 2010. View at Publisher · View at Google Scholar
  • Anna R. Laury, Jason L. Hornick, Ruth Perets, Jeffrey F. Krane, Joseph Corson, Ronny Drapkin, and Michelle S. Hirsch, “PAX8 Reliably Distinguishes Ovarian Serous Tumors From Malignant Mesothelioma,” American Journal Of Surgical Pathology, vol. 34, no. 5, pp. 627–635, 2010. View at Publisher · View at Google Scholar
  • Lindsey S. Treviño, James R. Giles, Wei Wang, Mary Ellen Urick, and Patricia Ann Johnson, “Gene Expression Profiling Reveals Differentially Expressed Genes in Ovarian Cancer of the Hen: Support for Oviductal Origin?,” Hormones and Cancer, vol. 1, no. 4, pp. 177–186, 2010. View at Publisher · View at Google Scholar
  • Theodore J. Brown, and Premalatha Shathasivam, “Maintaining Mesenchymal Properties of Ovarian Surface Epithelial Cells: A Potential Early Protective Role for TGF-beta in Ovarian Carcinogenesis,” Endocrinology, vol. 151, no. 11, pp. 5092–5094, 2010. View at Publisher · View at Google Scholar
  • Jing Zhang, Yan-Li Li, Cai-Yun Zhou, Yu-Ting Hu, and Huai-Zeng Chen, “Expression of octamer-4 in serous and mucinous ovarian carcinoma,” Journal of Clinical Pathology, vol. 63, no. 10, pp. 879–883, 2010. View at Publisher · View at Google Scholar
  • L. K. Mullany, H-Y Fan, Z. Liu, L. D. White, A. Marshall, P. Gunaratne, M. L. Anderson, C. J. Creighton, L. Xin, M. Deavers, K-K Wong, and J. S. Richards, “Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo,” Oncogene, vol. 30, no. 32, pp. 3522–3536, 2011. View at Publisher · View at Google Scholar
  • Francoise Gaudin, Salam Nasreddine, Anne-Claire Donnadieu, Dominique Emilie, Christophe Combadiere, Sophie Prevot, Veronique Machelon, and Karl Balabanian, “Identification of the Chemokine CX(3)CL1 as a New Regulator of Malignant Cell Proliferation in Epithelial Ovarian Cancer,” Plos One, vol. 6, no. 7, 2011. View at Publisher · View at Google Scholar
  • Pradeep S. Tanwar, LiHua Zhang, Tomoko Kaneko-Tarui, Michael D. Curley, Makoto M. Taketo, Poonam Rani, Drucilla J. Roberts, and Jose M. Teixeira, “Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/beta-Catenin and PTEN,” Plos One, vol. 6, no. 6, 2011. View at Publisher · View at Google Scholar
  • Anna R. Laury, Ruth Perets, Huiying Piao, Jeffrey F. Krane, Justine A. Barletta, Christopher French, Lucian R. Chirieac, Rosina Lis, Massimo Loda, Jason L. Hornick, Ronny Drapkin, and Michelle S. Hirsch, “A Comprehensive Analysis of PAX8 Expression in Human Epithelial Tumors,” American Journal Of Surgical Pathology, vol. 35, no. 6, pp. 816–826, 2011. View at Publisher · View at Google Scholar
  • P. Vercellini, P. Crosignani, E. Somigliana, P. Vigano, L. Buggio, G. Bolis, and L. Fedele, “The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention,” Human Reproduction, vol. 26, no. 9, pp. 2262–2273, 2011. View at Publisher · View at Google Scholar
  • Tess V. Clendenen, Eva Lundin, Anne Zeleniuch-Jacquotte, Karen L. Koenig, Franco Berrino, Annekatrin Lukanova, Anna E. Lokshin, Annika Idahl, Nina Ohlson, Goran Hallmans, Vittorio Krogh, Sabina Sieri, Paola Muti, Adele Marrangoni, Brian M. Nolen, Mengling Liu, Roy E. Shore, and Alan A. Arslan, “Circulating Inflammation Markers and Risk of Epithelial Ovarian Cancer,” Cancer Epidemiology Biomarkers & Prevention, vol. 20, no. 5, pp. 799–810, 2011. View at Publisher · View at Google Scholar
  • Susan Fotheringham, Keren Levanon, and Ronny Drapkin, “Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells,” Jove-Journal Of Visualized Experiments, no. 51, 2011. View at Publisher · View at Google Scholar
  • A. M. Karst, K. Levanon, and R. Drapkin, “Modeling high-grade serous ovarian carcinogenesis from the fallopian tube,” Proceedings of the National Academy of Sciences, vol. 108, no. 18, pp. 7547–7552, 2011. View at Publisher · View at Google Scholar
  • Maryam Rezvani, and Akram M. Shaaban, “Fallopian Tube Disease in the Nonpregnant Patient,” Radiographics, vol. 31, no. 2, pp. 527–U279, 2011. View at Publisher · View at Google Scholar
  • Veronique Machelon, Francoise Gaudin, Sophie Camilleri-Broet, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerome Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prevot, Philippe Broet, and Karl Balabanian, “CXCL12 expression by healthy and malignant ovarian epithelial cells,” Bmc Cancer, vol. 11, 2011. View at Publisher · View at Google Scholar
  • Amy L. Creekmore, William T. Silkworth, Daniela Cimini, Roderick V. Jensen, Paul C. Roberts, and Eva M. Schmelz, “Changes in Gene Expression and Cellular Architecture in an Ovarian Cancer Progression Model,” Plos One, vol. 6, no. 3, 2011. View at Publisher · View at Google Scholar
  • Andres Aguirre, Yasaman Ardeshirpour, Mary M. Sanders, Molly Brewer, and Quing Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Translational Oncology, vol. 4, no. 1, pp. 29–37, 2011. View at Publisher · View at Google Scholar
  • Martin Ligr, Ruzeen Rohintan Patwa, Garrett Daniels, Lorraine Pan, Xinyu Wu, Yirong Li, Liantian Tian, Zhenxing Wang, Ruliang Xu, Jingjing Wu, Fan Chen, Jinsong Liu, Jian-Jun Wei, and Peng Lee, “Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer,” Plos One, vol. 6, no. 10, 2011. View at Publisher · View at Google Scholar
  • R. J. M. Correa, T. Peart, Y. R. Valdes, G. E. DiMattia, and T. G. Shepherd, “Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids,” Carcinogenesis, vol. 33, no. 1, pp. 49–58, 2011. View at Publisher · View at Google Scholar
  • Johanne I. Weberpals, Madhuri Koti, and Jeremy A. Squire, “Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer,” Cancer Genetics, vol. 204, no. 10, pp. 525–535, 2011. View at Publisher · View at Google Scholar
  • Alison M. Karst, Keren Levanon, Sekhar Duraisamy, Joyce F. Liu, Michelle S. Hirsch, Jonathan L. Hecht, and Ronny Drapkin, “Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas,” Gynecologic Oncology, vol. 123, no. 1, pp. 5–12, 2011. View at Publisher · View at Google Scholar
  • Nikhil Sangle, Joel Webb, and Elke A. Jarboe, “Serous Carcinoma of the Fallopian Tube Presenting as Axillary Lymphadenopathy,” International Journal Of Gynecological Pathology, vol. 30, no. 1, pp. 53–57, 2011. View at Publisher · View at Google Scholar
  • Irena Conic, Irena Dimov, Desanka Tasic-Dimov, Biljana Djordjevic, and Vladisav Stefanovic, “Ovarian Epithelial Cancer Stem Cells,” Thescientificworldjournal, vol. 11, pp. 1243–1269, 2011. View at Publisher · View at Google Scholar
  • Ronny I. Drapkin, and Jonathan L. Hecht, “Pathogenesis of Ovarian Cancer,” Diagnostic Gynecologic and Obstetric Pathology, pp. 758–781, 2011. View at Publisher · View at Google Scholar
  • Alison M Karst, and Ronny Drapkin, “The new face of ovarian cancer modeling: better prospects for detection and treatment.,” F1000 medicine reports, vol. 3, pp. 22, 2011. View at Publisher · View at Google Scholar
  • Hua Jiang, Xiaolong Lin, Yingtao Liu, Wenjia Gong, Xiaoling Ma, Yinhua Yu, Yi Xie, Xiaoxi Sun, Youji Feng, Viktor Janzen, and Tong Chen, “Transformation of Epithelial Ovarian Cancer Stemlike Cells into Mesenchymal Lineage via EMT Results in Cellular Heterogeneity and Supports Tumor Engraftment,” Molecular Medicine, vol. 18, no. 8, pp. 1197–1208, 2012. View at Publisher · View at Google Scholar
  • Alicia A. Tone, Carl Virtanen, Patricia Shaw, and Theodore J. Brown, “Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis,” Clinical Cancer Research, vol. 18, no. 16, pp. 4334–4344, 2012. View at Publisher · View at Google Scholar
  • Na Lu Smith, Piri Welcsh, Joshua Z. Press, Kathy J. Agnew, Rochelle Garcia, and Elizabeth M. Swisher, “E2F3b over-expression in ovarian carcinomas and in BRCA1 Haploinsufficient fallopian tube epithelium,” Genes, Chromosomes and Cancer, vol. 51, no. 11, pp. 1054–1062, 2012. View at Publisher · View at Google Scholar
  • Ann E. Drummond, and Peter J. Fuller, “Activin and inhibin, estrogens and NF kappa B, play roles in ovarian tumourigenesis is there crosstalk?,” Molecular And Cellular Endocrinology, vol. 359, no. 1-2, pp. 85–91, 2012. View at Publisher · View at Google Scholar
  • Ludmila Szabova, Chaoying Yin, Sujata Bupp, Theresa M. Guerin, Jerome J. Schlomer, Deborah B. Householder, Maureen L. Baran, Ming Yi, Yurong Song, Wenping Sun, Jonathan E. McDunn, Philip L. Martin, Terry Van Dyke, and Simone Difilippantonio, “Perturbation of Rb, p53, and Brca1 or Brca2 Cooperate in Inducing Metastatic Serous Epithelial Ovarian Cancer,” Cancer Research, vol. 72, no. 16, pp. 4141–4153, 2012. View at Publisher · View at Google Scholar
  • Alison M Karst, and Ronny Drapkin, “Primary culture and immortalization of human fallopian tube secretory epithelial cells,” Nature Protocols, vol. 7, no. 9, pp. 1755–1764, 2012. View at Publisher · View at Google Scholar
  • Yongyi Wang, Andrea Sacchetti, Matthijs R. van Dijk, Marten van der Zee, Paul H. van der Horst, Rosalie Joosten, Curt W. Burger, J. Anton Grootegoed, Leen J. Blok, and Riccardo Fodde, “Identification of Quiescent, Stem-Like Cells in the Distal Female Reproductive Tract,” Plos One, vol. 7, no. 7, 2012. View at Publisher · View at Google Scholar
  • Weiwei Shan, Imelda Mercado-Uribe, Jing Zhang, Daniel Rosen, Shiwu Zhang, Jianjun Wei, and Jinsong Liu, “Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications,” Cell Cycle, vol. 11, no. 11, pp. 2107–2113, 2012. View at Publisher · View at Google Scholar
  • Frederic K. C. Fung, David W. Chan, Vincent W. S. Liu, Thomas H. Y. Leung, Annie N. Y. Cheung, and Hextan Y. S. Ngan, “Increased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression,” Plos One, vol. 7, no. 5, 2012. View at Publisher · View at Google Scholar
  • Payam Zahedi, Roshan Yoganathan, Micheline Piquette-Miller, and Christine Allen, “Recent advances in drug delivery strategies for treatment of ovarian cancer,” Expert Opinion on Drug Delivery, vol. 9, no. 5, pp. 567–583, 2012. View at Publisher · View at Google Scholar
  • Lisa K. Mullany, Zhilin Liu, Erin R. King, Kwong-Kwok Wong, and JoAnne S. Richards, “Wild-Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell Survival,” Endocrinology, vol. 153, no. 4, pp. 1638–1648, 2012. View at Publisher · View at Google Scholar
  • Katharine L. Sodek, K. Joan Murphy, Theodore J. Brown, and Maurice J. Ringuette, “Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis,” Cancer and Metastasis Reviews, vol. 31, no. 1-2, pp. 397–414, 2012. View at Publisher · View at Google Scholar
  • Maria Koutsaki, Apostolos Zaravinos, and Demetrios A. Spandidos, “Modern Trends into the Epidemiology and Screening of Ovarian Cancer. Genetic Substrate of the Sporadic Form,” Pathology & Oncology Research, vol. 18, no. 2, pp. 135–148, 2012. View at Publisher · View at Google Scholar
  • Yu-Chi Wang, Yi-Te Yo, Hsin-Yi Lee, Yu-Ping Liao, Tai-Kuang Chao, Po-Hsuan Su, and Hung-Cheng Lai, “ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome,” The American Journal of Pathology, vol. 180, no. 3, pp. 1159–1169, 2012. View at Publisher · View at Google Scholar
  • Kun-Ming Chen, Shang-Min Zhang, Cesar Aliaga, Yuan-Wan Sun, Timothy Cooper, Krishnegowda Gowdahalli, Junjia Zhu, Shantu Amin, and Karam El-Bayoumy, “Induction of Ovarian Cancer and DNA Adducts by Dibenzo[a,l]pyrene in the Mouse,” Chemical Research In Toxicology, vol. 25, no. 2, pp. 374–380, 2012. View at Publisher · View at Google Scholar
  • David A. Engler, Sumeet Gupta, Whitfield B. Growdon, Ronny I. Drapkin, Mai Nitta, Petra A. Sergent, Serena F. Allred, Jenny Gross, Michael T. Deavers, Wen-Lin Kuo, Beth Y. Karlan, Bo R. Rueda, Sandra Orsulic, David M. Gershenson, Michael J. Birrer, Joe W. Gray, and Gayatry Mohapatra, “Genome Wide DNA Copy Number Analysis of Serous Type Ovarian Carcinomas Identifies Genetic Markers Predictive of Clinical Outcome,” Plos One, vol. 7, no. 2, 2012. View at Publisher · View at Google Scholar
  • David W. Chan, Winnie W. Y. Hui, Patty C. H. Cai, Michelle X. Liu, Mingo M. H. Yung, Celia S. L. Mak, Thomas H. Y. Leung, Karen K. L. Chan, and Hextan Y. S. Ngan, “Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells,” Plos One, vol. 7, no. 12, 2012. View at Publisher · View at Google Scholar
  • P. S. Tanwar, T. Kaneko-Tarui, H.-J. Lee, L. Zhang, and J. M. Teixeira, “PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression,” Carcinogenesis, vol. 34, no. 4, pp. 893–901, 2012. View at Publisher · View at Google Scholar
  • C. Siristatidis, T. N. Sergentanis, P. Kanavidis, M. Trivella, M. Sotiraki, I. Mavromatis, T. Psaltopoulou, A. Skalkidou, and E. T. Petridou, “Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer--a systematic review and meta-analysis,” Human Reproduction Update, vol. 19, no. 2, pp. 105–123, 2012. View at Publisher · View at Google Scholar
  • Achuta Kumar Guddati, “Ovarian cancer stem cells: elusive targets for chemotherapy,” Medical Oncology, vol. 29, no. 5, pp. 3400–3408, 2012. View at Publisher · View at Google Scholar
  • Nuzhat Ahmed, Khalid Abubaker, Jock Findlay, and Michael Quinn, “Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance,” Journal of Cellular Biochemistry, vol. 114, no. 1, pp. 21–34, 2012. View at Publisher · View at Google Scholar
  • Chantel Samardzija, Michael Quinn, Jock K. Findlay, and Nuzhat Ahmed, “Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary,” Journal Of Ovarian Research, vol. 5, 2012. View at Publisher · View at Google Scholar
  • Danielle Vicus, William Small, and Allan Covens, “Ovarian Cancer,” Clinical Radiation Oncology, pp. 1277–1297, 2012. View at Publisher · View at Google Scholar
  • Mi Jeong Kwon, “Emerging Roles of Claudins in Human Cancer,” International Journal of Molecular Sciences, vol. 14, no. 9, pp. 18148–18180, 2013. View at Publisher · View at Google Scholar
  • Patricia Hoyer, Kathryn Coe, Lisa Hess, and G Swanson, “Ovarian Cancer,” Ovarian Toxicology, Second Edition, vol. 20134055, pp. 315–332, 2013. View at Publisher · View at Google Scholar
  • Chenguang Xi, Caixia Ren, Ajin Hu, Jie Lin, Qian Yao, Yue Wang, Zifen Gao, Xiuli An, and Congrong Liu, “Defective expression of Protein 4.1N is correlated to tumor progression, aggressive behaviors and chemotherapy resistance in epithelial ovarian cancer,” Gynecologic Oncology, 2013. View at Publisher · View at Google Scholar
  • Nuzhat Ahmed, Khalid Abubaker, and Jock K. Findlay, “Ovarian Cancer Stem Cells: Molecular Concepts and Relevance as Therapeutic Targets,” Molecular Aspects of Medicine, 2013. View at Publisher · View at Google Scholar
  • Maura Sonego, Monica Schiappacassi, Sara Lovisa, Alessandra Dall'Acqua, Marina Bagnoli, Francesca Lovat, Massimo Libra, Sara D'Andrea, Vincenzo Canzonieri, Loredana Militello, Marco Napoli, Giorgio Giorda, Barbara Pivetta, Delia Mezzanzanica, Mattia Barbareschi, Barbara Valeri, Silvana Canevari, Alfonso Colombatti, Barbara Belletti, Giannino Del Sal, and Gustavo Baldassarre, “Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer,” EMBO Molecular Medicine, vol. 5, no. 5, pp. 707–722, 2013. View at Publisher · View at Google Scholar
  • Matthew Schwede, Dimitrios Spentzos, Stefan Bentink, Oliver Hofmann, Benjamin Haibe-Kains, David Harrington, John Quackenbush, and Aedín C. Culhane, “Stem Cell-Like Gene Expression in Ovarian Cancer Predicts Type II Subtype and Prognosis,” PLoS ONE, vol. 8, no. 3, pp. e57799, 2013. View at Publisher · View at Google Scholar
  • Kevin M. Elias, S. Intidhar Labidi-Galy, Allison F. Vitonis, Jason L. Hornick, Leona A. Doyle, Michelle S. Hirsch, Daniel W. Cramer, and Ronny Drapkin, “Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms,” Gynecologic Oncology, 2013. View at Publisher · View at Google Scholar
  • Stacey N. Akers, Kirsten Moysich, Wa Zhang, Golda Collamat Lai, Austin Miller, Shashikant Lele, Kunle Odunsi, and Adam R. Karpf, “LINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients,” Gynecologic Oncology, 2013. View at Publisher · View at Google Scholar
  • Javier E. Girardini, Carolina Marotta, and Giannino Del Sal, “Disarming mutant p53 oncogenic function,” Pharmacological Research, 2013. View at Publisher · View at Google Scholar
  • J Kumar, F W Fraser, C Riley, N Ahmed, D R McCulloch, and A C Ward, “Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer,” British Journal of Cancer, 2013. View at Publisher · View at Google Scholar
  • Madhuri Koti, Robert J. Gooding, Paulo Nuin, Alexandria Haslehurst, Colleen Crane, Johanne Weberpals, Timothy Childs, Peter Bryson, Moyez Dharsee, Kenneth Evans, Harriet E. Feilotter, Paul C. Park, and Jeremy A. Squire, “Identification of the IGF1/PI3K/NF kappa B/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer,” Bmc Cancer, vol. 13, 2013. View at Publisher · View at Google Scholar
  • Tamara Kalir, Adolfo Firpo-Betancourt, and Farr Nezhat, “Update on ovarian cancer pathogenesis: history, controversies, emerging issues and future impact,” Expert Review of Obstetrics & Gynecology, pp. 1–9, 2013. View at Publisher · View at Google Scholar
  • P. S. Tanwar, G. Mohapatra, S. Chiang, D. A. Engler, L. Zhang, T. Kaneko-Tarui, Y. Ohguchi, M. J. Birrer, and J. M. Teixeira, “Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer,” Carcinogenesis, 2013. View at Publisher · View at Google Scholar
  • Ellen L. Goode, Melissa DeRycke, Kimberly R. Kalli, Ann L. Oberg, Julie M. Cunningham, Matthew J. Maurer, Brooke L. Fridley, Sebastian M. Armasu, Daniel J. Serie, Priya Ramar, Krista Goergen, Robert A. Vierkant, David N. Rider, Hugues Sicotte, Chen Wang, Boris Winterhoff, Catherine M. Phelan, Joellen M. Schildkraut, Rachel P. Weber, Ed Iversen, Andrew Berchuck, Rebecca Sutphen, Michael J. Birrer, Shalaka Hampras, Leah Preus, Simon A. Gayther, Susan J. Ramus, Nicolas Wentzensen, Hannah P. Yang, Montserrat Garcia-Closas, Honglin Song, Jonathan Tyrer, Paul P. D. Pharoah, Gottfried Konecny, Thomas A. Sellers, Roberta B. Ness, Lara E. Sucheston, Kunle Odunsi, Lynn C. Hartmann, Kirsten B. Moysich, and Keith L. Knutson, “Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian Cancer ,” Plos One, vol. 8, no. 1, 2013. View at Publisher · View at Google Scholar
  • Caroline E. Ford, Eve Jary, Sean Si Qian Ma, Sheri Nixdorf, Viola A. Heinzelmann-Schwarz, and Robyn L. Ward, “The Wnt Gatekeeper SFRP4 Modulates EMT, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells,” Plos One, vol. 8, no. 1, 2013. View at Publisher · View at Google Scholar
  • Achuta K. Guddati, and Shagufta Shaheen, “Characterization of disease progression in ovarian cancer by utilizing 'chemograms' of ovarian cancer stem cells,” Journal Of Chemotherapy, vol. 25, no. 3, pp. 184–191, 2013. View at Publisher · View at Google Scholar
  • Joana Assis, “Ovarian cancer and DNA repair: DNA ligase IV as a potential key,” World Journal of Clinical Oncology, vol. 4, no. 1, pp. 14, 2013. View at Publisher · View at Google Scholar
  • Paul Michael Jones, and Ronny Drapkin, “Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental Platforms.,” Frontiers in oncology, vol. 3, pp. 217, 2013. View at Publisher · View at Google Scholar
  • Qinglei Zhan, Chunmei Wang, and Saiming Ngai, “Ovarian Cancer Stem Cells: A New Target for Cancer Therapy,” BioMed Research International, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Chang K. Sung, Thomas Benjamin, Dawei Li, Erik Andrews, and Ronny Drapkin, “Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers,” Molecular Oncology, vol. 7, no. 3, pp. 419–427, 2013. View at Publisher · View at Google Scholar
  • Deirdre Lum, Richard Guido, Erika Rodriguez, Ted Lee, Suketu Mansuria, Lori D'Ambrosio, and R. Marshall Austin, “Brush Cytology of the Fallopian Tube and Implications in Ovarian Cancer Screening,” Journal of Minimally Invasive Gynecology, vol. 21, no. 5, pp. 851–856, 2014. View at Publisher · View at Google Scholar
  • Sirin A. I. Adham, Ibtisam Al Harrasi, Ibrahim Al Haddabi, Afrah Al Rashdi, Shadia Al Sinawi, Abdullah Al Maniri, Taher Ba-Omar, and Brenda L. Coomber, “Immunohistological Insight into the Correlation between Neuropilin-1 and Epithelial-Mesenchymal Transition Markers in Epithelial Ovarian Cancer,” Journal of Histochemistry & Cytochemistry, vol. 62, no. 9, pp. 619–631, 2014. View at Publisher · View at Google Scholar
  • Megan M. Emori, and Ronny Drapkin, “The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis,” Reproductive Biology and Endocrinology, vol. 12, 2014. View at Publisher · View at Google Scholar
  • Erin A. White, Hilary A. Kenny, and Ernst Lengyel, “Three-dimensional modeling of ovarian cancer,” Advanced Drug Delivery Reviews, 2014. View at Publisher · View at Google Scholar
  • Daniela Loessner, Boris Michael Holzapfel, and Judith Ann Clements, “Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses,” Advanced Drug Delivery Reviews, 2014. View at Publisher · View at Google Scholar
  • Maria Koutsaki, Demetrios Spandidos, and Apostolos Zaravinos, “Epithelial–mesenchymal transition-associated miRNAs in ovarian carcinoma, with highlight on the miR-200 family: Prognostic value and prospective role in ovarian cancer therapeutics,” Cancer Letters, 2014. View at Publisher · View at Google Scholar
  • Maree Bilandzic, and Kaye L. Stenvers, “Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time,” Jove-Journal of Visualized Experiments, no. 87, 2014. View at Publisher · View at Google Scholar
  • Rachel A. Davidowitz, Laura M. Selfors, Marcin P. Iwanicki, Kevin M. Elias, Alison Karst, Huiying Piao, Tan A. Ince, Michael G. Drage, Judy Dering, Gottfried E. Konecny, Ursula Matulonis, Gordon B. Mills, Dennis J. Slamon, Ronny Drapkin, and Joan S. Brugge, “Mesenchymal gene program–expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance,” Journal of Clinical Investigation, 2014. View at Publisher · View at Google Scholar
  • Xj He Xiangjun, J Yang Jing, Q Zhang Qi, H Cui Heng, and Yj Zhang Yujun, “Shortening of the 3 ' untranslated region: an important mechanism leading to overexpression of HMGA2 in serous ovarian cancer,” Chinese Medical Journal, vol. 127, no. 3, pp. 494–499, 2014. View at Publisher · View at Google Scholar
  • Alison M. Karst, Paul M. Jones, Natalie Vena, Azra H. Ligon, Joyce F. Liu, Michelle S. Hirsch, Dariush Etemadmoghadam, David D. L. Bowtell, and Ronny Drapkin, “Cyclin E1 Deregulation Occurs Early in Secretory Cell Transformation to Promote Formation of Fallopian Tube-Derived High-Grade Serous Ovarian Cancers,” Cancer Research, vol. 74, no. 4, pp. 1141–1152, 2014. View at Publisher · View at Google Scholar
  • S I Labidi-Galy, A Clauss, V Ng, S Duraisamy, K M Elias, H-Y Piao, S Ficarro, S Ganesan, G B Mills, J A Marto, R Drapkin, E Bilal, R A Davidowitz, Y Lu, G Badalian-Very, B Györffy, and U-B Kang, “Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors,” Oncogene, 2014. View at Publisher · View at Google Scholar
  • Brian S. Gloss, and Goli Samimi, “Epigenetic biomarkers in epithelial ovarian cancer,” Cancer Letters, vol. 342, no. 2, pp. 257–263, 2014. View at Publisher · View at Google Scholar
  • Angela Lau, Alexandra Kollara, Elizabeth St John, Alicia A. Tone, Carl Virtanen, Ellen M. Greenblatt, W. Allan King, and Theodore J. Brown, “Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: Implications for ovarian carcinogenesis,” Experimental Biology and Medicine, vol. 239, no. 1, pp. 24–32, 2014. View at Publisher · View at Google Scholar
  • Lisa K. Mullany, Zhilin Liu, Kwong-Kwok Wong, Victoria Deneke, Yi Athena Ren, Alan Herron, and JoAnne S. Richards, “Tumor Repressor Protein 53 and Steroid Hormones Provide a New Paradigm for Ovarian Cancer Metastases,” Molecular Endocrinology, vol. 28, no. 1, pp. 127–137, 2014. View at Publisher · View at Google Scholar
  • Jingfang Gao, Yihong Zhu, Mikael Nilsson, and Karin Sundfeldt, “TGF-ß isoforms induce EMT independent migration of ovarian cancer cells,” Cancer Cell International, vol. 14, no. 1, pp. 72, 2014. View at Publisher · View at Google Scholar
  • Jin Hyung Heo, Ji-ye Song, Ju-yeong Jeong, Gwangil Kim, Tae Heon Kim, Haeyoun Kang, Ah-young Kwon, and Hee Jung An, “Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer,” Journal of Clinical Pathology, pp. jclinpath-2015-203129, 2015. View at Publisher · View at Google Scholar
  • Zhilin Liu, Yi A. Ren, Stephanie A. Pangas, Jaye Adams, Wei Zhou, Diego H. Castrillon, Dagmar Wilhelm, and JoAnne S. Richards, “FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development,” Molecular Endocrinology, vol. 29, no. 7, pp. 1006–1024, 2015. View at Publisher · View at Google Scholar
  • Debora Lattuada, Francesca Uberti, Barbara Colciaghi, Vera Morsanuto, Elena Maldi, Diletta Francesca Squarzanti, Claudio Molinari, Renzo Boldorini, Alessandro Bulfoni, Paola Colombo, and Giorgio Bolis, “Fimbrial Cells Exposure to Catalytic Iron Mimics Carcinogenic Changes,” International Journal of Gynecological Cancer, vol. 25, no. 3, pp. 389–398, 2015. View at Publisher · View at Google Scholar
  • Rikki A. Cannioto, and Kirsten B. Moysich, “Epithelial ovarian cancer and recreational physical activity: A review of the epidemiological literature and implications for exercise prescription,” Gynecologic Oncology, 2015. View at Publisher · View at Google Scholar
  • I. G. Motevich, N. D. Strekal, N. M. Papko, M. I. Glebovich, A. V. Shulha, and S. A. Maskevich, “Application of X-Ray Fluorescence Analysis to Determine the Elemental Composition of Tissues from Different Ovarian Neoplasms,” Journal of Applied Spectroscopy, 2015. View at Publisher · View at Google Scholar
  • A Kwon, Gwang Il Kim, Ju Jeong, Ji Song, Kyu Kwack, Chan Lee, Hae Kang, Tae Kim, Jin Heo, and Hee An, “VAV3 overexpressed in cancer stem cells is a poor prognostic indicator in ovarian cancer patients,” Stem Cells and Development, pp. 150225100855006, 2015. View at Publisher · View at Google Scholar
  • Dimitra T. Stefanou, Aristotelis Bamias, Hara Episkopou, Soterios A. Kyrtopoulos, Maria Likka, Theodore Kalampokas, Stylianos Photiou, Nikos Gavalas, Petros P. Sfikakis, Meletios A. Dimopoulos, and Vassilis L. Souliotis, “Aberrant DNA Damage Response Pathways May Predict the Outcome of Platinum Chemotherapy in Ovarian Cancer,” Plos One, vol. 10, no. 2, 2015. View at Publisher · View at Google Scholar
  • Vinod Vathipadiekal, Victoria Wang, Wei Wei, Levi Waldron, Ronny Drapkin, Michael Gillette, Steven Skates, and Michael Birrer, “Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtua,” Clinical Cancer Research, vol. 21, no. 21, pp. 4960–4969, 2015. View at Publisher · View at Google Scholar
  • L. P. Madhubhani P. Hemachandra, Dong-Hui Shin, Usawadee Dier, James N. Iuliano, Sarah A. Engelberth, Larissa M. Uusitalo, Susan K. Murphy, and Nadine Hempel, “Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma,” Cancer Research, vol. 75, no. 22, pp. 4973–4984, 2015. View at Publisher · View at Google Scholar
  • Eric A. Benson, Todd C. Skaar, Yunlong Liu, Kenneth P. Nephew, and Daniela Matei, “Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study,” Plos One, vol. 10, no. 10, 2015. View at Publisher · View at Google Scholar
  • David Klinkebiel, Wa Zhang, Stacey N Akers, Kunle Odunsi, and Adam R Karpf, “DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer.,” Molecular cancer research : MCR, vol. 14, no. 9, pp. 787–94, 2016. View at Publisher · View at Google Scholar
  • Han-Li Huang, Min-Wu Chao, Ya-Chi Li, Li-Hsun Chang, Chun-Han Chen, Mei-Chuan Chen, Chun-Chun Cheng, Jing-Ping Liou, Che-Ming Teng, and Shiow-Lin Pan, “MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer,” Scientific Reports, vol. 6, pp. 31664, 2016. View at Publisher · View at Google Scholar
  • Marta Marco, and Paul R. Gill, “DDRs in Healthy and Cancerous Reproductive Systems,” Discoidin Domain Receptors in Health and Disease, pp. 155–179, 2016. View at Publisher · View at Google Scholar
  • Yingying Hu, Ling Yang, Yujie Yang, Yanyan Han, Yongbo Wang, Wen Liu, and Ji Zuo, “Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway,” Journal of Cellular and Molecular Medicine, 2016. View at Publisher · View at Google Scholar
  • Marcin P. Iwanicki, Hsing-Yu Chen, Claudia Iavarone, Ioannis K. Zervantonakis, Taru Muranen, Marián Novak, Tan A. Ince, Ronny Drapkin, and Joan S. Brugge, “Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition,” JCI Insight, vol. 1, no. 10, 2016. View at Publisher · View at Google Scholar
  • Seyed Mohammad Abedi, Alireza Mardanshahi, Roza Shahhosseini, and Seyed Jalal Hosseinimehr, “Nuclear medicine for imaging of epithelial ovarian cancer,” Future Oncology, 2016. View at Publisher · View at Google Scholar
  • S. Wang, A. Blois, T. El Rayes, J. F. Liu, M. S. Hirsch, K. Gravdal, S. Palakurthi, D. R. Bielenberg, L. A. Akslen, R. Drapkin, V. Mittal, and R. S. Watnick, “Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment,” Science Translational Medicine, vol. 8, no. 329, pp. 329ra34–329ra34, 2016. View at Publisher · View at Google Scholar
  • Jingfeng Qian, Fang Ding, Aiping Luo, Zhihua Liu, and Zhumei Cui, “Overexpression of S100A14 in human serous ovarian carcinoma,” Oncology Letters, vol. 11, no. 2, pp. 1113–1119, 2016. View at Publisher · View at Google Scholar
  • Amy L Shafrir, Megan S Rice, Mamta Gupta, Kathryn L Terry, Bernard A Rosner, Rulla M Tamimi, Jonathan L Hecht, and Shelley S Tworoger, “The association between reproductive and hormonal factors and ovarian cancer by estrogen-α and progesterone receptor status.,” Gynecologic oncology, vol. 143, no. 3, pp. 628–635, 2016. View at Publisher · View at Google Scholar
  • Wenbin Tang, Aimin Ren, Hongyang Xiao, Huizhen Sun, and Bin Li, “Highly expressed NRSN2 is related to malignant phenotype in ovarian cancer,” Biomedicine & Pharmacotherapy, 2016. View at Publisher · View at Google Scholar
  • Ju-Yeon Jeong, Hae-youn Kang, Tae-Heon Kim, Gwang-il Kim, Jin-Hyung Huh, Ah-Young Kwon, Se-Wha Kim, Sang-geun Jung, and Hee-Jung An, “MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3,” Cancer Letters, 2016. View at Publisher · View at Google Scholar
  • Subbulakshmi Karthikeyan, Daniel D Lantvit, Dam Hee Chae, and Joanna E Burdette, “Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.,” Oncotarget, vol. 7, no. 43, pp. 69871–69882, 2016. View at Publisher · View at Google Scholar
  • Danielle Vicus, William Small, and Allan Covens, “Ovarian Cancer,” Clinical Radiation Oncology, pp. 1264–1283.e5, 2016. View at Publisher · View at Google Scholar
  • Caner Saygin, Andrew Wiechert, Vinay S. Rao, Ravi Alluri, Elizabeth Connor, Praveena S. Thiagarajan, James S. Hale, Yan Li, Anastasia Chumakova, Awad Jarrar, Yvonne Parker, Daniel J. Lindner, Anil Belur Nagaraj, J. Julie Kim, Analisa DiFeo, Fadi W. Abdul-Karim, Chad Michener, Peter G. Rose, Robert DeBernardo, Haider Mahdi, Keith R. McCrae, Feng Lin, Justin D. Lathia, and Ofer Reizes, “CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors,” The Journal of Experimental Medicine, pp. jem.20170438, 2017. View at Publisher · View at Google Scholar
  • Beiguang Zhang, Ying Liu, Donghui Liu, and Lei Yang, “Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer,” Journal of Biosciences, 2017. View at Publisher · View at Google Scholar
  • Shuqing Wei, Jianwu Liu, Yuxia Shi, Xi Zhang, Yongming Yang, and Qingzhen Song, “Exploration of the sequential gene changes in epithelial ovarian cancer induced by carboplatin via microarray analysis,” Molecular Medicine Reports, vol. 16, no. 3, pp. 3155–3160, 2017. View at Publisher · View at Google Scholar
  • Kai-Ti Lin, Shu-Pin Sun, Jui-I Wu, and Lu-Hai Wang, “Low-dose glucocorticoids suppresses ovarian tumor growth and metastasis in an immunocompetent syngeneic mouse model,” Plos One, vol. 12, no. 6, pp. e0178937, 2017. View at Publisher · View at Google Scholar
  • N. Ellissa Baskind, and Vinay Sharma, “Follicular Fluid Hormone Profiles in Natural Cycle IVF Patients During Follicular Phase,” Development of In Vitro Maturation for Human Oocytes, pp. 105–128, 2017. View at Publisher · View at Google Scholar
  • D Basuli, L Tesfay, Z Deng, B Paul, Y Yamamoto, G Ning, W Xian, F McKeon, M Lynch, C P Crum, P Hegde, M Brewer, X Wang, L D Miller, N Dyment, F M Torti, and S V Torti, “Iron addiction: a novel therapeutic target in ovarian cancer,” Oncogene, 2017. View at Publisher · View at Google Scholar
  • Juanni Li, Kuan Hu, Guanghui Gong, Ding Zhu, Yixuan Wang, Hailing Liu, and Xiaoying Wu, “Upregulation of MiR-205 transcriptionally suppresses SMAD4 and PTEN and contributes to human ovarian cancer progression.,” Scientific reports, vol. 7, pp. 41330, 2017. View at Publisher · View at Google Scholar
  • Paul T. Kroeger, and Ronny Drapkin, “Pathogenesis and heterogeneity of ovarian cancer,” Current Opinion in Obstetrics and Gynecology, vol. 29, no. 1, pp. 26–34, 2017. View at Publisher · View at Google Scholar
  • Amrutha Ramachandran, Anupama Rajanbabu, Kiran Gulabrao Bagul, Keechilat Pavithran, and Dehannathparambil K. Vijaykumar, “Correlation of Pattern of Spread and Outcomes in Advanced Epithelial Ovarian Cancers,” Indian Journal of Surgical Oncology, 2017. View at Publisher · View at Google Scholar
  • Alicia A. Tone, “Taking the Tube,” Clinical Obstetrics and Gynecology, vol. 60, no. 4, pp. 697–710, 2017. View at Publisher · View at Google Scholar
  • Whasun Lim, Soomin Ryu, Fuller W. Bazer, Sung-Man Kim, and Gwonhwa Song, “Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar
  • S. Intidhar Labidi-Galy, Eniko Papp, Dorothy Hallberg, Noushin Niknafs, Vilmos Adleff, Michael Noe, Rohit Bhattacharya, Marian Novak, Siân Jones, Jillian Phallen, Carolyn A. Hruban, Michelle S. Hirsch, Douglas I. Lin, Lauren Schwartz, Cecile L. Maire, Jean-Christophe Tille, Michaela Bowden, Ayse Ayhan, Laura D. Wood, Robert B. Scharpf, Robert Kurman, Tian-Li Wang, Ie-Ming Shih, Rachel Karchin, Ronny Drapkin, and Victor E. Velculescu, “High grade serous ovarian carcinomas originate in the fallopian tube,” Nature Communications, vol. 8, no. 1, 2017. View at Publisher · View at Google Scholar
  • Kevin M Elias, Wojciech Fendler, Konrad Stawiski, Stephen J Fiascone, Allison F Vitonis, Ross S Berkowitz, Gyorgy Frendl, Panagiotis Konstantinopoulos, Christopher P Crum, Magdalena Kedzierska, Daniel W Cramer, and Dipanjan Chowdhury, “Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer,” eLife, vol. 6, 2017. View at Publisher · View at Google Scholar
  • So Youn Cha, Yeon ho Choi, Sohyun Hwang, Ju-Yeon Jeong, and Hee Jung An, “Clinical impact of microRNAs associated With cancer stem cells as a Prognostic factor in Ovarian Carcinoma,” Journal of Cancer, vol. 8, no. 17, 2017. View at Publisher · View at Google Scholar
  • L. Dubeau, and J. Teixeira, “Origins of Epithelial Ovarian Cancer,” Translational Advances in Gynecologic Cancers, pp. 3–17, 2017. View at Publisher · View at Google Scholar
  • Thingreila Muinao, Mintu Pal, and Hari Prasanna Deka Boruah, “Origins based clinical and molecular complexities of epithelial ovarian cancer,” International Journal of Biological Macromolecules, 2018. View at Publisher · View at Google Scholar
  • Michael Kleemann, Helga Schneider, Kristian Unger, Philip Sander, E. Marion Schneider, Pamela Fischer-Posovszky, René Handrick, and Kerstin Otte, “MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Andrew M Prantner, Catherine Yin, Kalika Kamat, Khushboo Sharma, Andrew C Lowenthal, Peter Bawden Madrid, and Nathalie Scholler, “Molecular imaging of mesothelin-expressing ovarian cancer with a human and mouse cross-reactive nanobody,” Molecular Pharmaceutics, 2018. View at Publisher · View at Google Scholar
  • Ruth Escalona, Emily Chan, George Kannourakis, Jock Findlay, and Nuzhat Ahmed, “The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression,” International Journal of Molecular Sciences, vol. 19, no. 2, pp. 450, 2018. View at Publisher · View at Google Scholar
  • Kun-Ming Chen, Yuan-Wan Sun, Timothy K. Cooper, Gabrielle Benitez, Cesar Aliaga, Junjia Zhu, Krishne Gowda, Shantu Amin, and Karam El-Bayoumy, “ Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p ]chrysene and Its Metabolites in the Mouse Ovary ,” Chemical Research in Toxicology, 2018. View at Publisher · View at Google Scholar
  • Nabil Abdalla, Robert Piorkowski, Michal Bachanek, Pawel Stanirowski, Krzysztof Cendrowski, and Wlodzimierz Sawicki, “Does the Risk of Ovarian Malignancy Algorithm Provide Better Diagnostic Performance Than HE4 and CA125 in the Presurgical Differentiation of Adnexal Tumors in Polish Women?,” Disease Markers, vol. 2018, pp. 1–12, 2018. View at Publisher · View at Google Scholar