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Journal of Oncology
Volume 2010, Article ID 950201, 7 pages
http://dx.doi.org/10.1155/2010/950201
Review Article

MicroRNAs as Novel Biomarkers for Breast Cancer

Department of Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland

Received 15 March 2009; Accepted 8 May 2009

Academic Editor: Ben Davidson

Copyright © 2010 H. M. Heneghan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [49 citations]

The following is the list of published articles that have cited the current article.

  • Helen M. Heneghan, Nicola Miller, Ronan Kelly, John Newell, and Michael J. Kerin, “Systemic miRNA-195 Differentiates Breast Cancer from Other Malignancies and Is a Potential Biomarker for Detecting Noninvasive and Early Stage Disease,” Oncologist, vol. 15, no. 7, pp. 673–682, 2010. View at Publisher · View at Google Scholar
  • Rajesh C. Miranda, Andrzej Z. Pietrzykowski, Yueming Tang, Pratheesh Sathyan, Dayne Mayfield, Ali Keshavarzian, Wayne Sampson, and Dale Hereld, “MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?,” Alcoholism-Clinical and Experimental Research, vol. 34, no. 4, pp. 575–587, 2010. View at Publisher · View at Google Scholar
  • Mitchell S. Stark, Sonika Tyagi, Derek J. Nancarrow, Glen M. Boyle, Anthony L. Cook, David C. Whiteman, Peter G. Parsons, Christopher Schmidt, Richard A. Sturm, and Nicholas K. Hayward, “Characterization of the Melanoma miRNAome by Deep Sequencing,” Plos One, vol. 5, no. 3, 2010. View at Publisher · View at Google Scholar
  • Belete Teferedegne, Haruhiko Murata, Mariam Quinones, Keith Peden, and Andrew M. Lewis, “Patterns of microRNA Expression in Non-Human Primate Cells Correlate with Neoplastic Development In Vitro,” Plos One, vol. 5, no. 12, 2010. View at Publisher · View at Google Scholar
  • Yuri D'Alessandra, Paolo Devanna, Federica Limana, Stefania Straino, Anna Di Carlo, Paola G. Brambilla, Mara Rubino, Maria Cristina Carena, Liana Spazzafumo, Marco De Simone, Barbara Micheli, Paolo Biglioli, Felice Achilli, Fabio Martelli, Stefano Maggiolini, Giancarlo Marenzi, Giulio Pompilio, and Maurizio C. Capogrossi, “Circulating microRNAs are new and sensitive biomarkers of myocardial infarction,” European Heart Journal, vol. 31, no. 22, pp. 2765–2773, 2010. View at Publisher · View at Google Scholar
  • Lucy Pigati, Sree C. S. Yaddanapudi, Ravi Iyengar, Dong-Ja Kim, Steven A. Hearn, David Danforth, Michelle L. Hastings, and Dominik M. Duelli, “Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells,” Plos One, vol. 5, no. 10, 2010. View at Publisher · View at Google Scholar
  • Koichi Murata, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Kohei Nishitani, Hiromu Ito, and Takashi Nakamura, “Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis,” Arthritis Research & Therapy, vol. 12, no. 3, 2010. View at Publisher · View at Google Scholar
  • Carina Roth, Brigitte Rack, Volkmar Mueller, Wolfgang Janni, Klaus Pantel, and Heidi Schwarzenbach, “Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer,” Breast Cancer Research, vol. 12, no. 6, 2010. View at Publisher · View at Google Scholar
  • Heidi Schwarzenbach, Dave S. B. Hoon, and Klaus Pantel, “Cell-free nucleic acids as biomarkers in cancer patients,” Nature Reviews Cancer, vol. 11, no. 6, pp. 426–437, 2011. View at Publisher · View at Google Scholar
  • Dustin M. Bermudez, Benjamin J. Herdrich, Junwang Xu, Robert Lind, David P. Beason, Marc E. Mitchell, Louis J. Soslowsky, and Kenneth W. Liechty, “Impaired Biomechanical Properties of Diabetic Skin Implications in Pathogenesis of Diabetic Wound Complications,” American Journal Of Pathology, vol. 178, no. 5, pp. 2215–2223, 2011. View at Publisher · View at Google Scholar
  • Kasey C. Vickers, Brian T. Palmisano, Bassem M. Shoucri, Robert D. Shamburek, and Alan T. Remaley, “MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins,” Nature Cell Biology, vol. 13, no. 4, pp. 423–U182, 2011. View at Publisher · View at Google Scholar
  • X. Rao, G. Di Leva, M. Li, F. Fang, C. Devlin, C. Hartman-Frey, M. E. Burow, M. Ivan, C. M. Croce, and K. P. Nephew, “MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways,” Oncogene, vol. 30, no. 9, pp. 1082–1097, 2011. View at Publisher · View at Google Scholar
  • Ailbhe M. McDermott, Helen M. Heneghan, Nicola Miller, and Michael J. Kerin, “The Therapeutic Potential of MicroRNAs: Disease Modulators and Drug Targets,” Pharmaceutical Research, vol. 28, no. 12, pp. 3016–3029, 2011. View at Publisher · View at Google Scholar
  • Jung Ah Lee, Hye Yoon Lee, Eun Sook Lee, Insun Kim, and Jeoung Won Bae, “Prognostic Implications of MicroRNA-21 Overexpression in Invasive Ductal Carcinomas of the Breast,” Journal of Breast Cancer, vol. 14, no. 4, pp. 269–275, 2011. View at Publisher · View at Google Scholar
  • Ravi P. Subramanian, Julia H. Wildschutte, Crystal Russo, and John M. Coffin, “Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses,” Retrovirology, vol. 8, 2011. View at Publisher · View at Google Scholar
  • Claire Corcoran, Anne M. Friel, Michael J. Duffy, John Crown, and Lorraine O'Driscoll, “Intracellular and Extracellular MicroRNAs in Breast Cancer,” Clinical Chemistry, vol. 57, no. 1, pp. 18–32, 2011. View at Publisher · View at Google Scholar
  • Kimberly Cole, Maria Tabernero, and Karen S. Anderson, “Biologic characteristics of premalignant breast disease,” Cancer Biomarkers, vol. 9, no. 1-6, pp. 177–192, 2011. View at Publisher · View at Google Scholar
  • Ibrahim A. Darwish, Tanveer A. Wani, Nasr Y. Khalil, and Diane A. Blake, “Novel automated flow-based immunosensor for real-time measurement of the breast cancer biomarker CA15-3 in serum,” Talanta, vol. 97, pp. 499–504, 2012. View at Publisher · View at Google Scholar
  • Xin Zhou, Catalin Marian, Kepher H. Makambi, Ourania Kosti, Bhaskar V. S. Kallakury, Christopher A. Loffredo, and Yun-Ling Zheng, “MicroRNA-9 as Potential Biomarker for Breast Cancer Local Recurrence and Tumor Estrogen Receptor Status,” Plos One, vol. 7, no. 6, 2012. View at Publisher · View at Google Scholar
  • José Juvenal Linhares, Marcos Azevedo, Adalberto Abraão Siufi, Cristina Valleta de Carvalho, Maria Del Carmen Garcia Molina Wolgien, Emmanuelle Coelho Noronha, Tatiana Carvalho de Souza Bonetti, and Ismael Dale Cotrim Guerreiro da Silva, “Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer,” BMC Medical Genetics, vol. 13, no. 1, 2012. View at Publisher · View at Google Scholar
  • Ye Sun, Kalvin J. Gregory, Nelson G. Chen, and Val Golovlev, “Rapid and direct microRNA quantification by an enzymatic luminescence assay,” Analytical Biochemistry, vol. 429, no. 1, pp. 11–17, 2012. View at Publisher · View at Google Scholar
  • Leah Morenos, Richard Saffery, Francoise Mechinaud, David Ashley, Ngaire Elwood, Jeffrey M Craig, and Nicholas C Wong, “Evaluation of microRNA expression in patient bone marrow aspirate slides.,” PloS one, vol. 7, no. 8, 2012. View at Publisher · View at Google Scholar
  • Jeannette T. Bensen, Chiu Kit Tse, Sarah J. Nyante, Jill S. Barnholtz-Sloan, Stephen R. Cole, and Robert C. Millikan, “Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study,” Cancer Causes & Control, vol. 24, no. 6, pp. 1099–1109, 2013. View at Publisher · View at Google Scholar
  • Leena Hilakivi-Clarke, Sonia de Assis, and Anni Warri, “Exposures to Synthetic Estrogens at Different Times During the Life, and Their Effect on Breast Cancer Risk,” Journal of Mammary Gland Biology and Neoplasia, vol. 18, no. 1, pp. 25–42, 2013. View at Publisher · View at Google Scholar
  • Weijie Chen, Fengfeng Cai, Bei Zhang, Zeinab Barekati, and Xiao Yan Zhong, “The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers,” Tumor Biology, vol. 34, no. 1, pp. 455–462, 2013. View at Publisher · View at Google Scholar
  • Martina Kutmon, Thomas Kelder, Pooja Mandaviya, Chris T. A. Evelo, and Susan L. Coort, “CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis,” Plos One, vol. 8, no. 12, 2013. View at Publisher · View at Google Scholar
  • Maya Kahan-Hanum, Yehonatan Douek, Rivka Adar, and Ehud Shapiro, “A library of programmable DNAzymes that operate in a cellular environment.,” Scientific reports, vol. 3, pp. 1535, 2013. View at Publisher · View at Google Scholar
  • A. Truini, S. Coco, A. Alama, C. Genova, C. Sini, M. G. Dal Bello, G. Barletta, E. Rijavec, G. Burrafato, F. Boccardo, and F. Grossi, “Role of microRNAs in malignant mesothelioma,” Cellular and Molecular Life Sciences, vol. 71, no. 15, pp. 2865–2878, 2014. View at Publisher · View at Google Scholar
  • Ellen Li, Stephanie Burke, Wei Zhu, Jennie L Williams, Ping Ji, Nengtai Ouyang, Yuanhao Zhang, Xin Yu Wang, Deborah C Rubin, Nicholas O Davidson, Roberto Bergamaschi, and Kenneth R Shroyer, “Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities.,” International journal of oncology, vol. 45, no. 2, pp. 587–94, 2014. View at Publisher · View at Google Scholar
  • Hilda Jiménez-Wences, Oscar Peralta-Zaragoza, and Gloria Fernández-Tilapa, “Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review).,” Oncology reports, vol. 31, no. 6, pp. 2467–76, 2014. View at Publisher · View at Google Scholar
  • Heidi Schwarzenbach, Naohiro Nishida, George A. Calin, and Klaus Pantel, “Clinical relevance of circulating cell-free microRNAs in cancer,” Nature Reviews Clinical Oncology, 2014. View at Publisher · View at Google Scholar
  • Giang T Nguyen-Dien, Robert A Smith, Larisa M Haupt, Lyn R Griffiths, and Hue T Nguyen, “Genetic polymorphisms in miRNAs targeting the estrogen receptor and their effect on breast cancer risk.,” Meta gene, vol. 2, pp. 226–36, 2014. View at Publisher · View at Google Scholar
  • Patrizia Dentelli, Laura Annaratone, Anna Sapino, Rita Falcioni, Maria Felice Brizzi, Matteo Traversa, Arturo Rosso, Gabriele Togliatto, Cristina Olgasi, Caterina Marchiò, Paolo Provero, Antonio Lembo, and Giulia Bon, “miR-221/222 control luminal breast cancer tumor progression by regulating different targets.,” Cell cycle (Georgetown, Tex.), vol. 13, no. 11, pp. 1811–26, 2014. View at Publisher · View at Google Scholar
  • Malik Yousef, Naim Najami, Loai Abedallah, and Waleed Khalifa, “Computational Approaches for Biomarker Discovery,” Journal of Intelligent Learning Systems and Applications, vol. 06, no. 04, pp. 153–161, 2014. View at Publisher · View at Google Scholar
  • G. B. Kunsbaeva, I. R. Gilyazova, V. N. Pavlov, and E. K. Khusnutdinova, “The role of miRNAs in the development of prostate cancer,” Russian Journal of Genetics, vol. 51, no. 7, pp. 627–641, 2015. View at Publisher · View at Google Scholar
  • Eman A. Toraih, Eman A. Mohammed, Sherif Farrag, Nevene Ramsis, and Somaya Hosny, “Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer Patients,” Molecular Diagnosis & Therapy, 2015. View at Publisher · View at Google Scholar
  • Yasemin Oztemur, Tufan Bekmez, Alp Aydos, Isik G. Yulug, Betul Bozkurt, and Bala Gur Dedeoglu, “A ranking-based meta-analysis reveals let-7 family as a meta-signature for grade classification in breast cancer,” PLoS ONE, vol. 10, no. 5, 2015. View at Publisher · View at Google Scholar
  • Dagnija Kalniete, Miki Nakazawa-Miklaševiča, Ilze Štrumfa, Arnis Āboliņš, Arvīds Irmejs, Jānis Gardovskis, and Edvīns Miklaševičs, “pHigh expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients,” Hereditary Cancer in Clinical Practice, vol. 13, no. 1, 2015. View at Publisher · View at Google Scholar
  • Cristina Cătană, George A. Calin, and Ioana Neagoe, “Inflamma-miRs in Aging and Breast Cancer: Are They Reliable Players?,” Frontiers in Medicine, vol. 2, 2015. View at Publisher · View at Google Scholar
  • Andrea Mathe, Rodney Scott, and Kelly Avery-Kiejda, “miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer,” International Journal of Molecular Sciences, vol. 16, no. 12, pp. 28347–28376, 2015. View at Publisher · View at Google Scholar
  • Mohammed Alsaweed, Peter Hartmann, Donna Geddes, and Foteini Kakulas, “MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother,” International Journal of Environmental Research and Public Health, vol. 12, no. 11, pp. 13981–14020, 2015. View at Publisher · View at Google Scholar
  • Mohammed Alsaweed, Anna R Hepworth, Christophe Lefèvre, Peter E Hartmann, Donna T Geddes, and Foteini Hassiotou, “Human Milk MicroRNA and Total RNA Differ Depending on Milk Fractionation.,” Journal of cellular biochemistry, vol. 116, no. 10, pp. 2397–407, 2015. View at Publisher · View at Google Scholar
  • Mahin Keshavarz, Mohsen Behpour, and Hossain-Ali Rafiee-pour, “Recent trends in electrochemical microRNA biosensors for early detection of cancer,” RSC Adv., vol. 5, no. 45, pp. 35651–35660, 2015. View at Publisher · View at Google Scholar
  • Qing Lv, Qiuxia Li, Peizhuo Zhang, Yingjuan Jiang, Xinwei Wang, Qiujing Wei, Shuangyan Cao, Zetao Liao, Zhiming Lin, Yunfeng Pan, Jianlin Huang, Tianwang Li, Ou Jin, Yuqiong Wu, and Jieruo Gu, “Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets,” BioMed Research International, vol. 2015, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • Dongguo Li, Hong Xia, Zhen-ya Li, Lin Hua, and Lin Li, “Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling,” BioMed Research International, vol. 2015, pp. 1–17, 2015. View at Publisher · View at Google Scholar
  • Shoichi Miyamoto, Tetsushi Nakao, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Jun Wang, Koji Ueyama, Takeshi Kimura, Koh Ono, Shunsuke Usami, Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Daihiko Hakuno, Yasuhiro Nakashima, Masataka Nishiga, and Masayasu Izuhara, “Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.,” PloS one, vol. 10, no. 11, 2015. View at Publisher · View at Google Scholar
  • Mohammed Alsaweed, Ching Lai, Peter Hartmann, Donna Geddes, and Foteini Kakulas, “Human Milk Cells Contain Numerous miRNAs that May Change with Milk Removal and Regulate Multiple Physiological Processes,” International Journal of Molecular Sciences, vol. 17, no. 6, pp. 956, 2016. View at Publisher · View at Google Scholar
  • Halimeh Mollainezhad, Nahid Eskandari, Abbasali Pourazar, Mansoor Salehi, and Alireza Andalib, “Expression of microRNA-370 in human breast cancer compare with normal samples.,” Advanced biomedical research, vol. 5, pp. 129, 2016. View at Publisher · View at Google Scholar
  • Eman A. Elghoroury, Mona H. Ibrahim, Solaf A. Kamel, Amany H. Abdelrahman, Hesham G. ElDin, Iman louai, Asmaa Mohammed, and Mahmoud M. Kamel, “Evaluation of miRNA-21 and miRNA Let-7 as Prognostic Markers in Breast Cancer Patients,” Clinical Breast Cancer, 2017. View at Publisher · View at Google Scholar