Patterns of Anthracycline-Based Chemotherapy-Induced Adverse Drug Reactions and Their Impact on Relative Dose Intensity among Women with Breast Cancer in Ethiopia: A Prospective Observational Study

Table 4

Determinants of overall RDI ≥ 85% among breast cancer patients who received AC and AC-T chemotherapy at TASH, from January 1 to September 30, 2017 GC, N = 146.

Factors	N (%)	COR	95% CI	value	AOR	95% CI	value
Neutropenia^#
Grade 0–2	88 (60.3%)	1	—	—	1	—	—
Grade¾	58 (39.7%)	0.714	0.56–0.91	0.006	0.26	0.116–0.581	0.001
Number of cycles received
Cycle 4	46 (31.5%)	1	—	—	1	—	—
Cycle 6	25 (17.1%)	1.277	0.35–4.66	0.711	1.58	0.415–5.995	0.504
Cycle 8	75 (51.4%)	0.345	0.146–0.817	0.016	0.28	0.11–0.695	0.006
Regimen
AC	71 (48.6%)	1	—	—	—	—	—
AC-T	75 (51.4%)	0.318	0.149–0.678	0.003	—	—	NS

AOR = adjusted odds ratio; COR = crude odds ratio; NS = not significant Other sociodemographic, pretreatment laboratory values or other clinical data explained in Table 1 and other toxicities explained in Table 2 above had no significant association with overall RDI ≥ 85% (using multivariate backward logistic regression). ^#Considering the maximum grade neutropenia reported during the follow-up as the toxicity grade for that patient.