Patterns of Anthracycline-Based Chemotherapy-Induced Adverse Drug Reactions and Their Impact on Relative Dose Intensity among Women with Breast Cancer in Ethiopia: A Prospective Observational Study
Table 5
Factors associated with the incidence of first cycle toxicity among study participants, N = 146.
Factors
Mean ± SD or N (%)
COR
value for COR
AOR
95% CI
value
Determinants of first cycle neutropenia
Baseline WBC
7.3 ± 2.40
0.756
0.005
—
—
NS
Baseline ANC
4.1 ± 1.97
0.670
0.002
0.670
0.519–0.867
0.002
Determinants of first cycle leukopenia
Baseline Hgb
13.9 ± 1.36
0.772
0.050
0.735
0.544–0.991
0.044
Baseline WBC
7.3 ± 2.40
0.712
0.002
0.718
0.583–0.885
0.002
Baseline ANC
4.1 ± 1.97
0.706
0.009
—
—
NS
Determinants of first cycle Anemia
Baseline Hgb
13.9 ± 1.36
0.345
0.339
0.206–0.558
Baseline ANC
4.1 ± 1.97
1.416
0.002
1.332
1.015–1.749
Baseline platelet
314.1 ± 110.6
1.005
0.034
—
—
NS
Baseline ALP
227.9 ± 212.1
1.003
0.042
—
—
NS
Tumor stage
Stage I and II
54 (37)
1
—
—
—
—
Stage III
62 (42)
4.08
0.037
—
—
NS
Stage IV
30 (21)
5.17
0.025
—
—
NS
Determinants of first cycle vomiting
Age
42.2 ± 11.5
0.963
0.015
0.964
0.935–0.994
0.021
Baseline WBC
7.3 ± 2.40
0.862
0.049
0.856
0.734–0.998
0.047
Baseline Hgb
13.9 ± 1.36
0.739
0.033
0.700
0.524–0.934
0.016
ALP, alkaline phosphatase; ANC, absolute neutrophil count; Hgb, hemoglobin; SD, standard deviation; WBC, white blood cell count. The baseline represents the pretreatment value. No association was found with other sociodemographic and clinical data explained in Table 1.
