Discovery and Validation of Circulating EVL mRNA as a Prognostic Biomarker in Pancreatic Cancer

Figure 1

Identification of mRNAs that are differentially regulated in the TCGA database and in microarray-based plasma mRNA expression profiles from PACA patients. (a), (b) Volcano plots and hierarchical clustering analyses were used to identify mRNAs that were differentially expressed between pancreatic tumor tissue and control samples in the TCGA dataset. (c), (d) Volcano plots and hierarchical clustering analyses were used to detect mRNAs that were differentially expressed between pancreatic tumor tissue and control samples in our microarray dataset. (e) Differentially expressed mRNAs were subjected to GO enrichment analyses of key biological processes, cellular components, and molecular functions. (f) Top enriched KEGG pathways for differentially expressed mRNAs in the present microarray dataset. The size of the circle represents the number of genes enriched in the pathway. Circle colors correspond to values. TCGA, The Cancer Genome Atlas; DE mRNA, differentially expressed mRNA; and KEGG, Kyoto Encyclopedia of Genes and Genomes.

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