Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy

Figure 1

Schematic of the PI3K/Akt/mTOR Pathway. pathway highlights downstream effectors pertinent to the development of diabetic retinopathy along with the benefit of dual inhibitors of mTOR (TORC1 and TORC2) that prevent feedback activation and prevent downstream effectors that are detrimental in the progression of diabetic retinopathy. References consulted for Figure 1: [56], Paloma Pharmaceuticals presentation files, and Angioceutics International.