Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2015, Article ID 152854, 7 pages
http://dx.doi.org/10.1155/2015/152854
Research Article

Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways

1Department of Ophthalmology, Show Chwan Memorial Hospital, No. 526, Sec. 1, Zhongshan Road, Changhua 500, Taiwan
2Institute of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
3Central Taiwan University of Science and Technology, No. 666, Buzih Road, Beitun District, Taichung 40601, Taiwan
4Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
5Department of Optometry, Yuan Pei University, Hsinchu 30015, Taiwan

Received 9 September 2015; Accepted 15 October 2015

Academic Editor: Qing-huai Liu

Copyright © 2015 Shih-Chun Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Ahmed, M. N. Lott, and D. M. Marcus, “The macular xanthophylls,” Survey of Ophthalmology, vol. 50, no. 2, pp. 183–193, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. A. J. Whitehead, J. A. Mares, and R. P. Danis, “Macular pigment: a review of current knowledge,” Archives of Ophthalmology, vol. 124, no. 7, pp. 1038–1045, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J. M. Seddon, U. A. Ajani, R. D. Sperduto et al., “Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration,” The Journal of the American Medical Association, vol. 272, no. 18, pp. 1413–1420, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. J. S. L. Tan, J. J. Wang, V. Flood, E. Rochtchina, W. Smith, and P. Mitchell, “Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye study,” Ophthalmology, vol. 115, no. 2, pp. 334–341, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. D. Pinazo-Durán, F. Gómez-Ulla, L. Arias et al., “Do nutritional supplements have a role in age macular degeneration prevention?” Journal of Ophthalmology, vol. 2014, Article ID 901686, 15 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Y. Chew, “Nutrition effects on ocular diseases in the aging eye,” Investigative Ophthalmology & Visual Science, vol. 54, no. 14, pp. ORSF42–ORSF47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Beatty, U. Chakravarthy, J. M. Nolan et al., “Secondary outcomes in a clinical trial of Carotenoids with Coantioxidants versus placebo in early age-related macular degeneration,” Ophthalmology, vol. 120, no. 3, pp. 600–606, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Ma, H.-L. Dou, Y.-Q. Wu et al., “Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis,” British Journal of Nutrition, vol. 107, no. 3, pp. 350–359, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Kijlstra, Y. Tian, E. R. Kelly, and T. T. J. M. Berendschot, “Lutein: more than just a filter for blue light,” Progress in Retinal and Eye Research, vol. 31, no. 4, pp. 303–315, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. X.-H. Jin, K. Ohgami, K. Shiratori et al., “Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats,” Investigative Ophthalmology & Visual Science, vol. 47, no. 6, pp. 2562–2568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. R.-R. He, B. Tsoi, F. Lan, N. Yao, X.-S. Yao, and H. Kurihara, “Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice,” Chinese Medicine, vol. 6, article 38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. C. R. H. Raetz and C. Whitfield, “Lipopolysaccharide endotoxins,” Annual Review of Biochemistry, vol. 71, pp. 635–700, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. J. T. Rosenbaum, H. O. McDevitt, R. B. Guss, and P. R. Egbert, “Endotoxin-induced uveitis in rats as a model for human disease,” Nature, vol. 286, no. 5773, pp. 611–613, 1980. View at Publisher · View at Google Scholar · View at Scopus
  14. F.-T. Chen, Y.-C. Liu, C.-M. Yang, and C.-H. Yang, “Anti-inflammatory effect of the proteasome inhibitor bortezomib on endotoxin-induced uveitis in rats,” Investigative Ophthalmology & Visual Science, vol. 53, no. 7, pp. 3682–3694, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-S. Mo, A. Matsukawa, S. Ohkawara, and M. Yoshinaga, “Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits,” Experimental Eye Research, vol. 68, no. 3, pp. 333–340, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. A. F. de Vos, V. N. A. Klaren, and A. Kijlstra, “Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat,” Investigative Ophthalmology & Visual Science, vol. 35, no. 11, pp. 3873–3883, 1994. View at Google Scholar · View at Scopus
  17. D.-N. Hu, S. A. McCormick, R. Ritch, and K. Pelton-Henrion, “Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes,” Investigative Ophthalmology & Visual Science, vol. 34, no. 7, pp. 2210–2219, 1993. View at Google Scholar · View at Scopus
  18. D.-N. Hu, M. Chen, D. Y. Zhang, F. Ye, S. A. McCormick, and C.-C. Chan, “Interleukin-1β increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-κB pathway,” Investigative Ophthalmology & Visual Science, vol. 52, no. 6, pp. 3767–3774, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. D.-N. Hu, M. Bi, D. Y. Zhang, F. Ye, S. A. McCormick, and C.-C. Chan, “Constitutive and LPS-induced expression of MCP-1 and IL-8 by human uveal melanocytes in vitro and relevant signal pathways,” Investigative Ophthalmology & Visual Science, vol. 55, no. 9, pp. 5760–5769, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. A. M. Abu El-Asrar, S. S. Al-Obeidan, D. Kangave et al., “CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis,” Immunobiology, vol. 216, no. 9, pp. 1004–1009, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. W. Thomson and M. T. Lotze, The Cytokine Handbook, Elsevier Science, San Diego, Calif, USA, 4th edition, 2003.
  22. N. Mukaida, A. Harada, and K. Matsushima, “Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions,” Cytokine & Growth Factor Reviews, vol. 9, no. 1, pp. 9–23, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. Q. Bian, T. Qin, Z. Ren, D. Wu, and F. Shang, “Lutein or zeaxanthin supplementation suppresses inflammatory responses in retinal pigment epithelial cells and macrophages,” in Retinal Degenerative Diseases, vol. 723 of Advances in Experimental Medicine and Biology, pp. 43–50, Springer, New York, NY, USA, 2012. View at Publisher · View at Google Scholar
  24. M. R. Ferrick, S. R. Thurau, M. H. Oppenheim et al., “Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1,” Investigative Ophthalmology & Visual Science, vol. 32, no. 5, pp. 1534–1539, 1991. View at Google Scholar · View at Scopus
  25. S. J. Curnow, F. Falciani, O. M. Durrani et al., “Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis,” Investigative Ophthalmology and Visual Science, vol. 46, no. 11, pp. 4251–4259, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Lahmar, A.-B. Ahmed, T. Abdelrahman et al., “Cytokine profiles in toxoplasmic and viral uveitis,” The Journal of Infectious Diseases, vol. 199, no. 8, pp. 1239–1249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Sasaki, Y. Ozawa, T. Kurihara et al., “Neuroprotective effect of an antioxidant, lutein, during retinal inflammation,” Investigative Ophthalmology and Visual Science, vol. 50, no. 3, pp. 1433–1439, 2009. View at Publisher · View at Google Scholar · View at Scopus