Journal of Ophthalmology

Journal of Ophthalmology / 2015 / Article

Letter to the Editor | Open Access

Volume 2015 |Article ID 212095 |

Gokhan Ozge, Onder Ayyildiz, Cem Ozgonul, Murat Kucukevcilioglu, Tarkan Mumcuoglu, "Comment on “Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis”", Journal of Ophthalmology, vol. 2015, Article ID 212095, 1 page, 2015.

Comment on “Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis”

Academic Editor: Vicente Zanon-Moreno
Received16 Sep 2015
Accepted07 Oct 2015
Published15 Oct 2015

We read with great interest the recently published article “Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis” by Sun et al. [1]. In this experimental study, researchers aimed to use reverse iontophoresis (RI) to extract iron from the anterior chamber noninvasively. However, we think that there are some points that should be emphasized and reconsidered about this study.

First, as is known, ocular siderosis is caused generally by penetrating eye injury. Intraocular foreign body is most of the time located in vitreous cavity and scleral and/or corneal laceration is seen after penetrating eye injuries. Chiquet et al. reported that, after penetrating eye injury, IOFBs are commonly located in retina (23%), vitreous (48%), sclera (16%), and anterior segment (13%). The common ocular findings upon admission were corneal wound (66%), prolapse or damage of the iris (48%), hyphema (42%), and lens damage (42%) [2]. In this study researchers used an eyecup placed around cornea to perform reverse iontophoresis. We are suspicious about its benefit for penetrating eye injury condition with sutured corneal laceration, corneal edema, and other anterior segment problems.

Our experimental study showed that surgery should be performed within 14 days after penetrating eye injury with iron foreign body [3]; RI might be used for patients without corneal wound as an adjuvant therapy to surgery.

Conflict of Interests

None of the authors has any conflict of interests to disclose.


  1. S. Sun, H. Diao, F. Zhao et al., “Extraction of iron from the rabbit anterior chamber with reverse iontophoresis,” Journal of Ophthalmology, vol. 2015, Article ID 425438, 8 pages, 2015. View at: Publisher Site | Google Scholar
  2. C. Chiquet, J.-C. Zech, P. Denis, P. Adeleine, and C. Trepsat, “Intraocular foreign bodies. Factors influencing final visual outcome,” Acta Ophthalmologica Scandinavica, vol. 77, no. 3, pp. 321–325, 1999. View at: Publisher Site | Google Scholar
  3. T. Mumcuoglu, G. Ozge, B. Soykut, O. Erdem, A. Gunal, and C. Acikel, “An animal model (guinea pig) of ocular siderosis: histopathology, pharmacology, and electrophysiology,” Current Eye Research, vol. 40, no. 3, pp. 314–320, 2015. View at: Publisher Site | Google Scholar

Copyright © 2015 Gokhan Ozge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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