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Journal of Ophthalmology
Volume 2015 (2015), Article ID 292615, 6 pages
http://dx.doi.org/10.1155/2015/292615
Research Article

ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa

Ophthalmology Unit, Department of Experimental, Diagnostic, and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Palagi 9, 40138 Bologna, Italy

Received 19 October 2014; Revised 9 December 2014; Accepted 15 December 2014

Academic Editor: Xinhua Shu

Copyright © 2015 Ernesto Strobbe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To assess endothelin-1 (ET-1) plasma levels, choroidal thickness, and aqueous flare in patients with early stage retinitis pigmentosa (RP) and to search for possible correlations. Methods. We compared 24 RP patients with 24 healthy controls. Choroidal thickness and aqueous flare were measured, respectively, by using a spectral domain optical coherence tomography and a laser flare-cell meter, whereas plasma samples were obtained from each patient to evaluate ET-1 plasma levels. Results. Notably, RP subjects showed significantly increased ET-1 plasma levels and reduced choroidal thickness compared with controls: versus  pg/mL, , and versus μm, , respectively. Higher aqueous flare values were also demonstrated in RP compared to controls: in detail, versus photon counts/ms, . Spearman’s correlation test highlighted that the increase of ET-1 plasma levels was related with the decrease of choroidal thickness (; ) and the increase of aqueous flare (; ). Conclusions. Early stage RP patients show a breakdown of blood-ocular barrier and increased ET-1 plasma levels and these findings may contribute to the reduction of choroidal thickness.