Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems

Figure 2

Optical coherence tomography time series follow-up after ocriplasmin in the porcine PVD model. (a–f) OCT follow up of a representative animal over time. A location-matched OCT is shown over a period of 5 weeks, from before injection until after PVD induction. SRF appears in week 2 (c) disappears by week 3 (d). PVD is observed in week 4 (e) and continues to enlarge in week 5 (f). For clarity, the inner retinal vessels in pigs are located more superficial on top of the inner limiting membrane; underneath these blood vessels, a prominent “shadow” can be observed in the OCT image caused by the opacity of the red blood cells in these vessels.

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