Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems

Figure 3

Effect of ocriplasmin on vitreoretinal architecture and extracellular matrix distribution in the porcine PVD model. (a–l) Representative histology images from porcine retinas 2 and 5 weeks after administration of vehicle or ocriplasmin. (a, b, and c: PAS; d, e, and f: laminin; g, h, and i: fibronectin; j, k, and l: collagen IV; d–l: specific stain in green, nuclei in blue). Scale bar: 100 μm. Large blood vessels which are situated superficially in the ILM in the pig. Arrowhead indicates ILM separation/PVD.