Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies in the meta-analysis.

First author and reference	Year	Ethnicity	Study design	Genotyping method	HWE reported	PCV			AMD			Control			Gene/loci investigated
						N	Male ratio	Mean age ± SD (yrs)	N	Male ratio	Mean age ± SD (yrs)	N	Male ratio	Mean age ± SD (yrs)
Nakata et al. [32]	2013	Japanese	1	TaqMan and Beadchip	Yes	581	0.73	72.59 ± 8.13	—	—	—	793	0.41	65.99 ± 4.33	CETP, LIPC, LPL
Zhang et al. [33]	2013	Chinese	1	PCR	Yes	250	0.66	65 ± 8.6	157	0.64	67 ± 9.21	204	0.61	69 ± 9	LIPC, ABCA1, CETP, LPL,
Li et al. [34]	2014	Chinese	1	PCR	Yes	298	0.62	66.8 ± 9.7	300	0.63	69.4 ± 8.9	296	0.48	65.1 ± 9.5	ABCA1
Liu et al. [13]	2014	Chinese	1	PCR	Yes	233	0.7	68.5 ± 5.9	200	0.55	75.3 ± 7.7	275	0.44	74.3 ± 7.6	ABCA1, LIPC, CETP, ABCG1
Meng et al. [36]	2015	Chinese	1	PCR	Yes	291	0.79	66.6 ± 9.6	230	0.63	69.3 ± 8.8	221	0.48	67.2 ± 9.6	CETP, LIPC, LPL
Li et al. [37]	2016	Chinese (Hong Kong)	1	TaqMan and PCR	Yes	236	0.69	68.5 ± 9	235	0.55	75.3 ± 7.6	365	0.42	74.4 ± 7.7	ABCG1
	2016	Chinese (Shantou)	1	TaqMan and PCR	Yes	187	0.72	63.1 ± 10.5	189	0.69	67.3 ± 10.1	670	0.43	73.8 ± 6.8	ABCG1
	2016	Japanese (Osaka)	1	TaqMan and PCR	Yes	204	0.77	72.2 ± 8.0	192	0.67	74.3 ± 7.3	157	0.33	47.9 ± 15.1	ABCG1
Qiao et al. [38]	2017	Chinese (Hong Kong)	1	Beadchip	Yes	156	—	—	310	—	—	1006	—	—	CETP

The characteristics of the eligible studies are shown. PCV: polypoidal choroidal vasculopathy; AMD: age-related macular degeneration; HWE: Hardy–Weinberg equilibrium.