Journal of Ophthalmology

Current Concepts and Future Developments of Corneal Cross-Linking

Publishing date
07 Nov 2014
Submission deadline
20 Jun 2014

Lead Editor

1Center for Refractive Surgery, Eye Department at the St. Francis Hospital, 48145 Münster, Germany

2Cornea and Refractive Surgery Department, International Medical Center, Dubai, UAE

3School of Medicine, New York University, New York, NY, USA

4Avedro, Inc., Waltham, MA, USA

Current Concepts and Future Developments of Corneal Cross-Linking


Prior to the advent of riboflavin-UVA mediated corneal collagen cross-linking (CXL), no conservative treatment for keratoconus existed. CXL was introduced as a technique to stabilize the structurally weak corneas of patients with keratoconus and halt the progression of the disease. Over the past decade, this method has revolutionized the treatment of corneal ectatic disorders, including keratoconus and post-LASIK ectasia.

More recently, the clinical use of cross-linking procedures has expanded to include transepithelial treatments, modified riboflavin formulations, accelerated illumination protocols, and pulsed illumination. Additionally, a variety of indications for cross-linking beyond the treatment of ectasia have been identified, including treatment of nonectatic corneal disorders such as infectious keratitis.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the pathology of the underlying disorders in which CXL is utilized, the development of cross-linking protocols to treat these conditions, and the evaluation of the outcomes of these procedures.

We are particularly interested in articles describing the new modalities and measuring outcomes from treatment trials; advances in keratoconus detection and invivo diagnostics; new insights into the mechanism of cross-linking using animal models; current concepts in the treatment of keratoconus using various forms of cross-linking and including alternatives like corneal implants and grafting. Potential topics include, but are not limited to:

  • Recent developments in keratoconus research including epidemiology
  • History and mechanism of cross-linking
  • Advances in genetics and in vivo diagnostics of keratoconus and corneas at risk-for-ectasia following LASIK
  • Latest technologies for clinical evaluation and measuring outcomes of cross-linking
  • Role of riboflavin and additives as well as oxygen in cross-linking
  • Role of transepithelial cross-linking
  • Role of high fluence cross-linking
  • Role of cross-linking in infectious corneal disease
  • Role of CXL in the treatment of corneal edema and bullous keratopathy
  • Indication and contraindication criteria for cross-linking in children
  • Recent advances in selective cross-linking for refractive correction

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2015
  • - Article ID 302983
  • - Editorial

Current Concepts and Future Developments of Corneal Cross-Linking

Suphi Taneri | Elias Jarade | ... | David Muller
  • Special Issue
  • - Volume 2015
  • - Article ID 690961
  • - Clinical Study

Rate of Corneal Collagen Crosslinking Redo in Private Practice: Risk Factors and Safety

Joelle Antoun | Elise Slim | ... | Elias F. Jarade
  • Special Issue
  • - Volume 2015
  • - Article ID 514834
  • - Research Article

Safety and Visual Outcome of Visian Toric ICL Implantation after Corneal Collagen Cross-Linking in Keratoconus: Up to 2 Years of Follow-Up

Rafic Antonios | Ali Dirani | ... | Elias Jarade
  • Special Issue
  • - Volume 2014
  • - Article ID 579190
  • - Research Article

Corneal Biomechanical Changes after Crosslinking for Progressive Keratoconus with the Corneal Visualization Scheimpflug Technology

Johannes Steinberg | Toam Katz | ... | Stephan J. Linke
  • Special Issue
  • - Volume 2014
  • - Article ID 568128
  • - Clinical Study

Clinical Outcomes after Complete Intracorneal Ring Implantation and Corneal Collagen Cross-Linking in an Intrastromal Pocket in One Session for Keratoconus

Pavel Studeny | Deli Krizova | Zbynek Stranak
  • Special Issue
  • - Volume 2014
  • - Article ID 890823
  • - Review Article

Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking

Amanda C. da Paz | Patrícia A. Bersanetti | ... | Paulo Schor
  • Special Issue
  • - Volume 2014
  • - Article ID 614380
  • - Clinical Study

Evaluation of Epithelial Integrity with Various Transepithelial Corneal Cross-Linking Protocols for Treatment of Keratoconus

Suphi Taneri | Saskia Oehler | ... | H. Burkhard Dick
  • Special Issue
  • - Volume 2014
  • - Article ID 604731
  • - Clinical Study

Pulsed Light Accelerated Crosslinking versus Continuous Light Accelerated Crosslinking: One-Year Results

Cosimo Mazzotta | Claudio Traversi | ... | Miguel Rechichi
Journal of Ophthalmology
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Acceptance rate12%
Submission to final decision133 days
Acceptance to publication15 days
Journal Citation Indicator0.630
Impact Factor1.9
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