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Journal of Osteoporosis
Volume 2010, Article ID 157323, 6 pages
Research Article

Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice

1Department of Veterinary Biosciences, University of Illinois, 2001 S. Lincoln Avenue, Urbana, IL 61802, USA
2Department of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
3Department of Medicine, University of Arizona, P.O. Box 245218, Tucson, AZ 85724, USA
4Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA

Received 4 November 2009; Accepted 28 May 2010

Academic Editor: Klaus Engelke

Copyright © 2010 Zelieann R. Craig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous work showed that retaining residual ovarian tissue protects young mice from accelerated bone loss following ovarian failure. The present study was designed to determine whether this protection is also present in aged animals. Aged (9–12 months) C57BL/6Hsd female mice were divided into: CON (vehicle), VCD (160 mg/kg; 15d), or OVX (ovariectomized). Lumbar BMD was monitored by DXA and CT used to assess vertebral microarchitecture. BMD was not different between VCD and CON at any time point but was lower ( ) than baseline, starting 1 month after ovarian failure in VCD and OVX mice. Following CT analysis there were no differences between CON and VCD, but OVX mice had lower bone volume fraction, trabecular thickness, and a trend for decreased connectivity density. These findings provide evidence that retention of residual ovarian tissue may protect aged follicle-depleted mice from accelerated bone loss to a lesser extent than that observed in young mice.