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Journal of Osteoporosis
Volume 2011, Article ID 732560, 7 pages
http://dx.doi.org/10.4061/2011/732560
Research Article

Mikkeli Osteoporosis Index Identifies Fracture Risk Factors and Osteoporosis and Intervention Thresholds Parallel with FRAX

1Department of Orthopaedics, Mikkeli Central Hospital, 50100 Mikkeli, Finland
2Department of Orthopaedics, Kuopio University Hospital, 70211 Kuopio, Finland
3Bone and Cartilage Research Unit (BCRU), Clinical Research Center, Kuopio University, 70211 Kuopio, Finland
4Department of Statistics, Kuopio University, 70211 Kuopio, Finland
5Department of Obstetrics and Gynaecology, Kuopio University Hospital, 70211 Kuopio, Finland

Received 7 December 2010; Accepted 1 March 2011

Academic Editor: Manuel Diaz Curiel

Copyright © 2011 Ville Juhana Waris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoporosis Index (MOI) was developed from Fracture Index (FI), a validated fracture risk score, to identify also osteoporosis. MOI risk factors are age, weight, previous fracture, family history of hip fracture or spinal osteoporosis, smoking, shortening of the stature, and use of arms to rise from a chair. The association of these risk factors with BMD was examined in development cohorts of 300 Finnish postmenopausal women with a fracture and in a population control of 434 women aged 65–72. Validation cohorts included 200 fracture patients and a population control of 943 women aged 58–69. MOI identified femoral neck osteoporosis in these cohorts as well as the Osteoporosis Self-Assessment Tool (OST). In the pooled fracture cohort, the association of BMI-based FRAX fracture risk with MOI was good. After BMD measurement, MOI identified well FRAX hip fracture risk-based Intervention Thresholds (ITs) (AUC 0.74–0.90).