Mikkeli Osteoporosis Index Identifies Fracture Risk Factors and Osteoporosis and Intervention Thresholds Parallel with FRAX

Table 2

Proportion of variance in BMD in Development Cohort 1 (fracture patients, 𝑁=300, age 45-79) and Development Cohort 2 (FPS, 𝑁=434, age 65-72). 𝑅² value (%), explained by the risk factors in univariate regression models, and by MOI, FI, and OST-scores.

Fracture patients
𝑁=300	𝑅^2; BMD-N	𝑅^2; BMD-H	𝑅^2; BMD-S
Weight, continuous	0.14***	0.19***	0.12***
Weight, categorized	0.13***	0,17***	0.12***
Age, continuous	0.13***	0.07***	0.01
Age, categorized	0.12***	0.07***	0.0
Shortening, continuous	0.08***	0.06***	0.02*
Shortening, categorized	0.05***	0.03*	0.01
Family history	0.01	0.0	0.0
Smoking	0.0	0.01	0.01
Rise from a chair test	0.0	0.02*	0.0
MOI	0.22***	0.22***	0.0
FI	0.08***	0.07***	0.0
OST	0.25***	0.25***	0.0
FPS
𝑁=434	𝑅^2; BMD-N	𝑅^2; BMD-H	𝑅^2; BMD-S
Weight, continuous	0.05***	0.12***	0.09***
Weight, categorized	0.06***	0.12***	0.09***
Age, continuous
Age, categorized
Shortening, continuous	0.01*	0.01	0.01
Shortening, categorized	0.03***	0.03***	0.02**
Fracture history	0.03***	0.03***	0.04***
Family history	0.0	0.01*	0.0
Smoking	0.0	0.0	0.01
Rise from a chair test	0.0	0.02*	0.0
MOI	0.11***	0.17***	0.11***
FI	0.04***	0.06***	0.03**
OST	0.06***	0.12***	0.19***

MOI: Mikkeli Osteoporosis Index; FI: Fracture Index; OST: Osteoporosis Self-Assessment Tool. Other abbreviations, see Table 1.