Evidence-Based Prevention of Preeclampsia: Commonly Asked Questions in Clinical Practice

Table 1

Indication for aspirin and risk factors according to SOMANZ, NICE, USPSTF, and ACOG. Table 1 is reproduced from Wertaschnigg et al. (2019) [36] [under the Creative Commons Attribution License/public domain].

SOMANZ-RANZOG	NICE 2010	USPSTF 2014	ACOG 2018
Indication for Aspirin:	Indication for Aspirin:	Indication for Aspirin:	Indication for Aspirin:
2 moderate or 1 high risk factor	2 moderate or 1 high risk factor	1 high risk factor	1 high risk factor
Dose: unclear	Dose: 75 mg/d from 12 weeks	Dose: 81 mg/d optimally before 16 weeks	Dose: 81 mg/d optimally before 16 weeks
Until 37 weeks or until delivery	Continue daily until delivery.	Continue daily until delivery.	Continue daily until delivery.
	Consider Aspirin:	Consider Aspirin:
		If more than one moderate risk factor	Other established medical indications
(i) Risk factors	High risk factors	High risk factors	High risk factors
(ii) Previous pregnancy with PE	(i) Previous pregnancy with PE	(i) Previous pregnancy with PE	(i) Previous pregnancy with PE
(iii) chronic hypertension	(ii) Chronic hypertension	(ii) Chronic hypertension	(ii) Chronic hypertension
(iv) Autoimmune disease	(iii) Autoimmune disease	(iii) Systemic lupus erythematosus	(iii) Systemic lupus erythematosus
(v) Diabetes mellitus	(iv) Diabetes mellitus	(iv) Diabetes mellitus	(iv) Diabetes mellitus
(vi) Chronic kidney disease	(v) Chronic kidney disease	(v) Chronic kidney disease	(v) Chronic kidney disease
(vii) Multifetal gestation		(vi) Multifetal gestation	(vi) Multifetal gestation
(viii) Nulliparity		(vii) Thrombophilia	(vii) Thrombophilia
(ix) Age >40 years	Moderate risk factors	Moderate risk factors	Moderate risk factors
(x) Inter-pregnancy interval >10 years	(i) Nulliparity	(i) Nulliparity	(i) Nulliparity
(xi) BMI at first visit >35 kg/m^2	(ii) Age >40 years	(ii) Age >35 years	(ii) Age >35 years
(xii) Family history of PE	(iii) Inter-pregnancy interval >10 years	(iii) Inter-pregnancy interval >10 years	(iii) Inter-pregnancy interval >10 years
(xiii) Conception by IVF	(iv) BMI at first visit >35 kg/m^2	(iv) BMI >30 kg/m2	(iv) BMI >30 kg/m2
(xiv) any risk factor	(v) Family history of PE	(v) Family history of PE	(v) Family history of PE
		(vi) History of SGA or adverse outcome	(vi) History of SGA or adverse outcome
		(vii) Sociodemographic characteristics (African American race or low socioeconomic status)	(vii) Sociodemographic characteristics (African American race or low socioeconomic status)

BMI: body mass index; IVF: in vitro fertilisation; PE: preeclampsia; SGA: small-for-gestational-age;