Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva

Table 1

Characteristics of two types of squamous cell carcinoma of the vulva. (Characteristics of the warty/basaloid type and the keratinizing type of SCC of the vulva are shown).

	warty or basaloid type	keratinizing type
Frequency	20%–35%	65%–80%
Age	Younger	Older
	55 (35–65)	77 (55–85)
Precursor	warty or basaloid VIN	Lichen sclerosus differentiated VIN
Molecular characteristics	HPV integration	p53 mutation
	p14^ARF ⋅p16^INK4a overexpression	Microsatellite instability
Prognosis	better	worse