Journal of Skin Cancer / 2011 / Article / Tab 1

Review Article

Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva

Table 1

Characteristics of two types of squamous cell carcinoma of the vulva. (Characteristics of the warty/basaloid type and the keratinizing type of SCC of the vulva are shown).

warty or basaloid typekeratinizing type

Frequency20%–35%65%–80%
AgeYoungerOlder
55 (35–65)77 (55–85)
Precursorwarty or basaloid VINLichen sclerosus differentiated VIN
Molecular characteristicsHPV integrationp53 mutation
overexpressionMicrosatellite instability
Prognosisbetterworse