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Journal of Skin Cancer
Volume 2012 (2012), Article ID 907543, 11 pages
Review Article

Patched Knockout Mouse Models of Basal Cell Carcinoma

1Department of Human Genetics, University Medical Center Göttingen, Heinrich-Düker Weg 12, 37073 Göttingen, Germany
2Department of Neuropathology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany

Received 12 July 2012; Accepted 6 August 2012

Academic Editor: Deric L. Wheeler

Copyright © 2012 Frauke Nitzki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation due to Ptch mutations on an immunocompetent background) and should allow for (i) BCC induction at a defined time point, (ii) analysis of defined BCC stages, and (iii) induction of BCC in 100% of animals. In addition, it should be easy to handle. Here, we compare several currently existing conventional and conditional Ptch knockout mouse models for BCC and their potential use in preclinical research. In addition, we provide new data using conditional 𝑃 𝑑 𝑐 β„Ž 𝑓 𝑙 π‘œ π‘₯ / 𝑓 𝑙 π‘œ π‘₯ mice and the 𝐾 5 - 𝐢 π‘Ÿ 𝑒 - 𝐸 𝑅 𝑇 + / βˆ’ driver.