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Journal of Toxicology
Volume 2011, Article ID 503576, 7 pages
http://dx.doi.org/10.1155/2011/503576
Research Article

Toxicity of Volatile Methylated Species of Bismuth, Arsenic, Tin, and Mercury in Mammalian Cells In Vitro

1Institute of Hygiene and Occupational Medicine, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany
2Institute of Environmental Analytical Chemistry, University of Duisburg-Essen, Universitaetsstraße 3-5, 45141 Essen, Germany

Received 13 June 2011; Revised 8 August 2011; Accepted 8 August 2011

Academic Editor: Michael Aschner

Copyright © 2011 E. Dopp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Feldmann and A. V. Hirner, “Occurrence of volatile metal and metalloid species in landfill and sewage gases,” International Journal of Environmental Analytical Chemistry, vol. 60, pp. 339–359, 1995. View at Google Scholar
  2. J. Meyer, A. Schmidt, K. Michalke, and R. Hensel, “Volatilisation of metals and metalloids by the microbial population of an alluvial soil,” Systematic and Applied Microbiology, vol. 30, no. 3, pp. 229–238, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Michalke, E. B. Wickenheiser, M. Mehring, A. V. Hirner, and R. Hensel, “Production of volatile derivatives of metal(loid)s by microflora involved in anaerobic digestion of sewage sludge,” Applied and Environmental Microbiology, vol. 66, no. 7, pp. 2791–2796, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. R. A. Diaz-Bone and T. van de Wiele, “Biotransformation of metal(loid)s by intestinal microorganisms,” Pure and Applied Chemistry, vol. 82, no. 2, pp. 409–427, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Boertz, L. M. Hartmann, M. Sulkowski et al., “Determination of trimethylbismuth in the human body after ingestion of colloidal bismuth subcitrate,” Drug Metabolism and Disposition, vol. 37, no. 2, pp. 352–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. R. A. Diaz-Bone and T. R. van de Wiele, “Biovolatilization of metal(loid)s by intestinal microorganisms in the simulator of the human intestinal microbial ecosystem,” Environmental Science and Technology, vol. 43, no. 14, pp. 5249–5256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Hollmann, J. Boertz, E. Dopp, J. Hippler, and A. V. Hirner, “Parallel on-line detection of a methylbismuth species by hyphenated GC/EI-MS/ICP-MS technique as evidence for bismuth methylation by human hepatic cells,” Metallomics, vol. 2, no. 1, pp. 52–56, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Wang, S. D. Holladay, D. C. Wolf, S. A. Ahmed, and J. L. Robertson, “Reproductive and developmental toxicity of arsenic in rodents: a review,” International Journal of Toxicology, vol. 25, no. 5, pp. 319–331, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. H. Tseng, “Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective,” Journal of Environmental Science and Health C, vol. 25, no. 1, pp. 1–22, 2007. View at Publisher · View at Google Scholar
  10. U. Schuhmacherwolz, H. H. Dieter, D. Klein, and K. Schneider, “Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects,” Critical Reviews in Toxicology, vol. 39, no. 4, pp. 271–298, 2009. View at Publisher · View at Google Scholar
  11. E. Dopp, L. M. Hartmann, A. M. Florea, A. W. Rettenmeier, and A. V. Hirner, “Environmental distribution, analysis, and toxicity of organometal(loid) compounds,” Critical Reviews in Toxicology, vol. 34, no. 3, pp. 301–333, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Dopp, A. D. Kligerman, and R. A. Diaz-Bone, “Organoarsenicals. Uptake, metabolism, and toxicity,” in Organometallics in Environment and Toxicology, A. Sigl, H. Sigl, and R. K. O. Sigl, Eds., vol. 7, The Royal Society of Chemistry, Cambridge, UK, 2010. View at Google Scholar
  13. G. J. Myers and P. W. Davidson, “Prenatal methylmercury exposure and children: neurologic, developmental, and behavioral research,” Environmental Health Perspectives, vol. 106, supplement 3, pp. 841–847, 1998. View at Google Scholar · View at Scopus
  14. T. W. Clarkson and J. J. Strain, “Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations,” Journal of Nutrition, vol. 133, no. 5, supplement 1, pp. 1539S–1543S, 2003. View at Google Scholar · View at Scopus
  15. D. A. Geier, P. G. King, L. K. Sykes, and M. R. Geier, “A comprehensive review of mercury provoked autism,” Indian Journal of Medical Research, vol. 128, no. 4, pp. 383–411, 2008. View at Google Scholar · View at Scopus
  16. K. Yamanaka, M. Hoshino, M. Okamoto, R. Sawamura, A. Hasegawa, and S. Okada, “Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical,” Biochemical and Biophysical Research Communications, vol. 168, no. 1, pp. 58–64, 1990. View at Google Scholar · View at Scopus
  17. K. Kato, K. Yamanaka, A. Hasegawa, and S. Okada, “Active arsenic species produced by GSH-dependent reduction of dimethylarsinic acid cause micronuclei formation in peripheral reticulocytes of mice,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 539, no. 1-2, pp. 55–63, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Andrewes, K. T. Kitchin, and K. Wallace, “Dimethylarsine and trimethylarsine are potent genotoxins in vitro,” Chemical Research in Toxicology, vol. 16, no. 8, pp. 994–1003, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Dopp, L. M. Hartmann, A. M. Florea et al., “Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells,” Toxicology and Applied Pharmacology, vol. 201, no. 2, pp. 156–165, 2004. View at Publisher · View at Google Scholar
  20. E. Dopp, L. M. Hartmann, U. von Recklinghausen et al., “The cyto- and genotoxicity of organotin compounds is dependent on the cellular uptake capability,” Toxicology, vol. 232, no. 3, pp. 226–234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Dopp, L. M. Hartmann, U. von Recklinghausen et al., “Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-/genotoxicity in fibroblasts and hepatoma cells,” Toxicological Sciences, vol. 87, no. 1, pp. 46–56, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Dopp, U. Von Recklinghausen, L. M. Hartmann et al., “Subcellular distribution of inorganic and methylated arsenic compounds in human urothelial cells and human hepatocytes,” Drug Metabolism and Disposition, vol. 36, no. 5, pp. 971–979, 2008. View at Publisher · View at Google Scholar
  23. U. von Recklinghausen, L. M. Hartmann, S. Rabieh et al., “Methylated bismuth, but not bismuth citrate or bismuth glutathione, induces cyto- and genotoxic effects in human cells in vitro,” Chemical Research in Toxicology, vol. 21, no. 6, pp. 1219–1228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Styblo, S. V. Serves, W. R. Cullen, and D. J. Thomas, “Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols,” Chemical Research in Toxicology, vol. 10, pp. 27–33, 1997. View at Google Scholar
  25. O. Ostling and K. J. Johanson, “Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells,” Biochemical and Biophysical Research Communications, vol. 123, no. 1, pp. 291–298, 1984. View at Google Scholar · View at Scopus
  26. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Experimental Cell Research, vol. 175, no. 1, pp. 184–191, 1988. View at Google Scholar · View at Scopus
  27. P. Gwynne, “Researchers' deaths inspire actions to improve safety,” The Scientist, vol. 11, p. 21, 1997. View at Google Scholar
  28. C. C. Bridges and R. K. Zalups, “Molecular and ionic mimicry and the transport of toxic metals,” Toxicology and Applied Pharmacology, vol. 204, no. 3, pp. 274–308, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Ehrenstein, P. Shu, E. B. Wickenheiser et al., “Methyl mercury uptake and associations with the induction of chromosomal aberrations in Chinese hamster ovary (CHO) cells,” Chemico-Biological Interactions, vol. 141, no. 3, pp. 259–274, 2002. View at Publisher · View at Google Scholar
  30. Z. Drobná, F. S. Walton, D. S. Paul, W. Xing, D. J. Thomas, and M. Stýblo, “Metabolism of arsenic in human liver: the role of membrane transporters,” Archives of Toxicology, vol. 84, no. 1, pp. 3–16, 2010. View at Publisher · View at Google Scholar
  31. M. J. Mass, A. Tennant, B. C. Roop et al., “Methylated trivalent arsenic species are genotoxic,” Chemical Research in Toxicology, vol. 14, no. 4, pp. 355–361, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Ahmad, K. T. Kitchin, and W. R. Cullen, “Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin,” Toxicology Letters, vol. 133, no. 1, pp. 47–57, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Nesnow, B. C. Roop, G. Lambert et al., “DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species,” Chemical Research in Toxicology, vol. 15, no. 12, pp. 1627–1634, 2002. View at Publisher · View at Google Scholar
  34. A. D. Kligerman, C. L. Doerr, A. H. Tennant et al., “Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations,” Environmental and Molecular Mutagenesis, vol. 42, no. 3, pp. 192–205, 2003. View at Publisher · View at Google Scholar
  35. H. R. Rawls, M. V. Marshall, H. L. Cardenas, H. R. Bhagat, and I. Cabasso, “Cytotoxicity evaluation of a new radiopaque resin additive-triphenyl bismuth,” Dental Materials, vol. 8, no. 1, pp. 54–59, 1992. View at Google Scholar · View at Scopus