Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing
A minimal kinetic model for enhanced wound healing with botulinum toxin. Wounding of the normal tissue state is assumed to occur most rapidly leading to an initial wound state of the tissue. Healing from a significant wound is typically a slow process taking weeks or months. In the meantime, without treatment, this system enters, at a moderate rate, into a vicious cycle state (Figure 2) from which its escape represents a very slow healing process. With botulinum toxin treatment, this cycle is blocked thus allowing the tissue to return to the normal state by the slow healing route. The four-step reaction of toxin binding, translocation, internalization, and toxicity is described elsewhere . A competing reaction is depicted as the slow decay or the inactivation rate of this toxin () that leads to a recurrence of symptoms.
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