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Journal of Tropical Medicine
Volume 2012, Article ID 639304, 7 pages
Review Article

Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani

1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
2Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, QC, Canada

Received 12 April 2011; Accepted 21 May 2011

Academic Editor: Christian Engwerda

Copyright © 2012 Rashmi Bankoti and Simona Stäger. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immunity to pathogens requires generation of effective innate and adaptive immune responses. Leishmania donovani evades these host defense mechanisms to survive and persist in the host. A better understanding and identification of mechanisms that L. donovani employs for its survival is critical for developing novel therapeutic interventions that specifically target the parasite. This paper will highlight some of the mechanisms that the parasite utilizes for its persistence and also discuss how the immune response is regulated.