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Journal of Thyroid Research
Volume 2011, Article ID 841949, 7 pages
Review Article

Thyroid Antibodies and Miscarriage: Where Are We at a Generation Later?

George Washington University School of Medicine and Health Sciences, 2300 Eye Street, Ross Hall, Suite 712, Washington, DC 20037, USA

Received 4 February 2011; Accepted 10 March 2011

Academic Editor: Bijay Vaidya

Copyright © 2011 Alex Stagnaro-Green. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In 1990, an association between thyroid antibody positivity and spontaneous miscarriage was first reported. A generation has passed since the initial observation. Over that time a robust literature has developed which has confirmed the initial finding and expanded upon it. The present paper reviews the literature that has been generated over the last twenty years on the following topics: (1) thyroid antibodies and spontaneous miscarriage, (2) thyroid antibodies and recurrent abortion, (3) etiology of pregnancy loss in thyroid antibody positive women, and (4) discussion of future research directions.