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Journal of Thyroid Research
Volume 2012, Article ID 736161, 6 pages
http://dx.doi.org/10.1155/2012/736161
Review Article

The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy

Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou Street, 11528 Athens, Greece

Received 5 September 2011; Accepted 17 October 2011

Academic Editor: Juan Carlos Galofré

Copyright © 2012 Leonidas H. Duntas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. H. Parry, Collections from the Unpublished Medical Writings of the Late Caleb Hillier Parry, vol. 2, Underwood, London, UK, 1982.
  2. R. Graves, “Newly observed affection of the thyroid: clinical lectures,” The London Medical and Surgical Journal, vol. 7, pp. 516–517, 1835. View at Google Scholar
  3. K. von Basedow, “Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhöhle,” Wochenschr Heilkunde, vol. 6, pp. 197–204, 1840. View at Google Scholar
  4. A. P. Weetman, “Graves' disease,” The New England Journal of Medicine, vol. 343, no. 17, pp. 1236–1248, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. R. Volpe, “Grave’s disease. Pathogenesis,” in Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text, L. E. Braverman and R. D. Utiger, Eds., pp. 648–657, J. B. Lippincott, Philadelphia, Pa, USA, 6th edition, 1986. View at Google Scholar
  6. N. Manji, J. D. Carr-Smith, K. Boelaert et al., “Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype,” The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 12, pp. 4873–4880, 2006. View at Publisher · View at Google Scholar · View at PubMed
  7. L. Chiovato and A. Pinchera, “Stressful life events and Graves' disease,” European Journal of Endocrinology, vol. 134, no. 6, pp. 680–682, 1996. View at Google Scholar · View at Scopus
  8. L. Bartalena, F. Bogazzi, M. L. Tanda, L. Manetti, E. Dell'Unto, and E. Martino, “Cigarette smoking and the thyroid,” European Journal of Endocrinology, vol. 133, no. 5, pp. 507–512, 1995. View at Google Scholar · View at Scopus
  9. A. B. Emiliano, L. Governale, M. Parks, and D. S. Cooper, “Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008,” The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 5, pp. 2227–2233, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. C. Marcocci, G. J. Kahaly, G. E. Krassas et al., “Selenium and the course of mild Graves' orbitopathy,” The New England Journal of Medicine, vol. 364, no. 20, pp. 1920–1931, 2011. View at Publisher · View at Google Scholar · View at PubMed
  11. M. Rotondi, E. Lazzeri, P. Romagnani, and M. Serio, “Role for interferon-γ inducible chemokines in endocrine autoimmunity: an expanding field,” Journal of Endocrinological Investigation, vol. 26, no. 2, pp. 177–180, 2003. View at Google Scholar · View at Scopus
  12. B. S. Prabhakar, R. S. Bahn, and T. J. Smith, “Current perspective on the pathogenesis of Graves' disease and ophthalmopathy,” Endocrine Reviews, vol. 24, no. 6, pp. 802–835, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. S. Bahn, “Pathophysiology of Graves’ ophthalmopathy: the cycle of disease,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 5, pp. 1939–1946, 2003. View at Google Scholar
  14. T. J. Smith, “Pathogenesis of Graves' orbitopathy: a 2010 update,” Journal of Endocrinological Investigation, vol. 33, no. 6, pp. 414–421, 2010. View at Google Scholar
  15. R.S. Bahn, “Mechanisms of disease-Graves’ ophthalmopathy,” The New England Journal of Medicine, vol. 362, pp. 726–738, 2010. View at Google Scholar
  16. W. M. Wiersinga, “Autoimmunity in Graves' ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors?” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 8, pp. 2386–2394, 2011. View at Publisher · View at Google Scholar · View at PubMed
  17. L. Bartalena, M. L. Tanda, E. Piantanida, and A. Lai, “Oxidative stress and Graves' ophthalmopathy: in vitro studies and therapeutic implications,” BioFactors, vol. 19, no. 3-4, pp. 155–163, 2003. View at Google Scholar · View at Scopus
  18. M. Aslan, N. Cosar, H. Celik et al., “Evaluation of oxidative status in patients with hyperthyroidism,” Endocrine, vol. 40, no. 2, pp. 285–289, 2011. View at Publisher · View at Google Scholar · View at PubMed
  19. H. Kohler and H. Jenzer, “Interaction of lactoperoxidase with hydrogen peroxide. Formation of enzyme intermediates and generation of free radicals,” Free Radical Biology & Medicine, vol. 6, no. 3, pp. 323–339, 1989. View at Google Scholar · View at Scopus
  20. E. Ademoǧlu, N. Özbey, Y. Erbil et al., “Determination of oxidative stress in thyroid tissue and plasma of patients with Graves' disease,” European Journal of Internal Medicine, vol. 17, no. 8, pp. 545–550, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. C. C. Tsai, S. B. Wu, C. Y. Cheng et al., “Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves ophthalmopathy: evidence that oxidative stress has a role in this disorder,” Eye, vol. 24, no. 9, pp. 1520–1525, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. J. W. Tomlinson, O. M. Durrani, I. J. Bujalska et al., “The role of 11β-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy,” The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 1, pp. 398–406, 2010. View at Publisher · View at Google Scholar · View at PubMed
  23. A. K. Eckstein, M. Plicht, H. Lax et al., “Thyrotropin receptor autoantibodies are independent risk factors for graves' ophthalmopathy and help to predict severity and outcome of the disease,” The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 9, pp. 3464–3470, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. J. Orgiazzi and A. M. Madec, “Reduction of the risk of relapse after withdrawal of medical therapy for Graves' disease,” Thyroid, vol. 12, no. 10, pp. 849–853, 2002. View at Google Scholar · View at Scopus
  25. M. N. Stan and R. S. Bahn, “Risk factors for development or deterioration of Graves' ophthalmopathy,” Thyroid, vol. 20, no. 7, pp. 777–783, 2010. View at Google Scholar · View at Scopus
  26. L. Bartalena, C. Marcocci, F. Bogazzi, M. Panicucci, A. Lepri, and A. Pinchera, “Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism,” The New England Journal of Medicine, vol. 321, no. 20, pp. 1349–1352, 1989. View at Google Scholar · View at Scopus
  27. A. Lai, L. Sassi, E. Compri et al., “Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent Graves' orbitopathy: a retrospective cohort study,” The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 3, pp. 1333–1337, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. L. Bartalena, C. Marcocci, F. Bogazzi et al., “Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy,” The New England Journal of Medicine, vol. 338, no. 2, pp. 73–78, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. L. Bartalena, “The dilemma of how to manage Graves' hyperthyroidism in patients with associated orbitopathy,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 3, pp. 592–599, 2011. View at Publisher · View at Google Scholar · View at PubMed
  30. P. Laurberg, D. C. Berman, S. Andersen, and I. B. Pedersen, “Sustained control of graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe graves' orbitopathy,” Thyroid, vol. 21, no. 9, pp. 951–956, 2011. View at Publisher · View at Google Scholar · View at PubMed
  31. L. Elbers, M. Mourits, and W. Wiersinga, “Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy,” Thyroid, vol. 21, no. 3, pp. 279–283, 2011. View at Publisher · View at Google Scholar · View at PubMed
  32. L. Bartalena, A. Pinchera, and C. Marcocci, “Management of graves' ophthalmopathy: reality and perspectives,” Endocrine Reviews, vol. 21, no. 2, pp. 168–199, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. M. P. Mourits, L. Koornneef, W. M. Wiersinga, M. F. Prummel, A. Berghout, and R. van der Gaag, “Clinical criteria for the assessment of disease activity in Graves' ophthalmology: a novel approach,” British Journal of Ophthalmology, vol. 73, no. 8, pp. 639–644, 1989. View at Google Scholar · View at Scopus
  34. G. Vannucchi, I. Campi, M. Bonomi et al., “Rituximab treatment in patients with active Graves' orbitopathy: effects on proinflammatory and humoral immune reactions,” Clinical & Experimental Immunology, vol. 161, no. 3, pp. 436–443, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. M. Salvi, G. Vannucchi, I. Campi, and P. Beck-Peccoz, “Rituximab in the treatment of thyroid eye disease: science fiction?” Orbit, vol. 28, no. 4, pp. 251–255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. E. A. Bouzas, P. Karadimas, G. Mastorakos, and D. A. Koutras, “Antioxidant agents in the treatment of Graves' ophthalmopathy,” American Journal of Ophthalmology, vol. 129, no. 5, pp. 618–622, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. V. B. Vrca, F. Skreb, I. Cepelak, Z. Romic, and L. Mayer, “Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium,” Clinica Chimica Acta, vol. 341, no. 1-2, pp. 55–63, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. T. Wertenbruch, H. S. Willenberg, C. Sagert et al., “Serum selenium levels in patients with remission and relapse of Graves' disease,” Medicinal Chemistry, vol. 3, no. 3, pp. 281–284, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. L. H. Duntas, “Selenium and the thyroid: a close-knit connection,” The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 12, pp. 5180–5188, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. M. Kihara, K. Kontani, A. Yamauchi et al., “Expression of thioredoxin in patients with Graves' disease,” International Journal of Molecular Medicine, vol. 15, no. 5, pp. 795–799, 2005. View at Google Scholar · View at Scopus
  41. P. Venditti, S. Di Meo, and T. De Leo, “Effect of thyroid state on characteristics determining the susceptibility to oxidative stress of mitochondrial fractions from rat liver,” Cellular Physiology and Biochemistry, vol. 6, no. 5, pp. 283–295, 1996. View at Google Scholar · View at Scopus
  42. M. Abalovich, S. Llesuy, S. Gutierrez, and M. Repetto, “Peripheral parameters of oxidative stress in Graves' disease: the effects of methimazole and 131 iodine treatments,” Clinical Endocrinology, vol. 59, no. 3, pp. 321–327, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. L. H. Duntas, “The role of selenium in thyroid autoimmunity and cancer,” Thyroid, vol. 16, no. 5, pp. 455–460, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. A. Seven, O. Seymen, S. Hatemi, H. Hatemi, G. Yiǧit, and G. Candan, “Antioxidant status in experimental hyperthyroidism: effect of vitamin E supplementation,” Clinica Chimica Acta, vol. 256, no. 1, pp. 65–74, 1996. View at Publisher · View at Google Scholar · View at Scopus
  45. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” The New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Zhang, W. Yu, J. L. Hargrove et al., “Inhibition of TNF-α induced ICAM-1, VCAM-1 and E-selectin expression by selenium,” Atherosclerosis, vol. 161, no. 2, pp. 381–386, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. N. Xia, S. Zhou, Y. Liang et al., “CD4+ T cells and the Th1/Th2 imbalance are implicated in the pathogenesis of Graves' ophthalmopathy,” International Journal of Molecular Medicine, vol. 17, no. 5, pp. 911–916, 2006. View at Google Scholar · View at Scopus
  48. Y. Chang, S. L. Piao, S. Gao, and D. M. Zheng, “Regulatory effects of micronutrient complex on the expression of Th1 and Th2 cytokines in diabetic C57BL mice,” Wei Sheng Yan Jiu, vol. 34, no. 1, pp. 64–66, 2005. View at Google Scholar · View at Scopus
  49. Y. Hiromatsu, D. Yang, T. Bednarczuk, I. Miyake, K. Nonaka, and Y. Inoue, “Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy,” The Journal of Clinical Endocrinology & Metabolism, vol. 85, no. 3, pp. 1194–1199, 2000. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. B. Li, J. Y. Han, W. Jiang, and J. Wang, “Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells,” Molecular Biology Reports, vol. 38, no. 4, pp. 2301–2306, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. E. B. Y. Konuk, O. Konuk, M. Misirlioglu, A. Menevse, and M. Unal, “Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves' ophthalmopathy patients,” European Journal of Endocrinology, vol. 155, no. 5, pp. 681–685, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus