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Journal of Thyroid Research
Volume 2013 (2013), Article ID 124538, 5 pages
http://dx.doi.org/10.1155/2013/124538
Review Article

Thyroid Hormone and Wound Healing

Section of Endocrinology, Boston University School of Medicine, Room M-1016, 715 Albany Street, Boston, MA 02118, USA

Received 29 January 2013; Accepted 9 February 2013

Academic Editor: Constantinos Pantos

Copyright © 2013 Joshua D. Safer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3 has accelerated wound healing and hair growth in rodents. Topical T4 has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cells in vitro and in vivo which may portend the use of thyroid hormone to promote wound healing.