Table of Contents Author Guidelines Submit a Manuscript
Journal of Transplantation
Volume 2011, Article ID 783168, 7 pages
http://dx.doi.org/10.1155/2011/783168
Review Article

Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan

Received 18 May 2011; Revised 29 June 2011; Accepted 13 July 2011

Academic Editor: Antonello Pileggi

Copyright © 2011 Hirofumi Noguchi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. J. Shapiro, J. R. T. Lakey, E. A. Ryan et al., “Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen,” The New England Journal of Medicine, vol. 343, no. 4, pp. 230–238, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. E. A. Ryan, J. R. T. Lakey, R. V. Rajotte et al., “Clinical outcomes and insulin secretion after islet transplantation with the edmonton protocol,” Diabetes, vol. 50, no. 4, pp. 710–719, 2001. View at Google Scholar · View at Scopus
  3. J. F. Markmann, S. Deng, N. M. Desai et al., “The use of non-heart-beating donors for isolated pancreatic islet transplantation,” Transplantation, vol. 75, no. 9, pp. 1423–1429, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. H. A. Clayton, S. M. Swift, J. M. Turner, R. F. L. James, and P. R. F. Bell, “Non-heart-beating organ donors: a potential source of islets for transplantation,” Transplantation, vol. 69, no. 10, pp. 2094–2098, 2000. View at Google Scholar · View at Scopus
  5. H. Noguchi, Y. Yamada, T. Okitsu et al., “Secretory unit of islet in transplantation (SUIT) and engrafted islet rate (EIR) indexes are useful for evaluating single islet transplantation,” Cell Transplantation, vol. 17, no. 1-2, pp. 121–128, 2008. View at Google Scholar · View at Scopus
  6. H. Noguchi, Y. Iwanaga, T. Okitsu, H. Nagata, Y. Yonekawa, and S. Matsumoto, “Evaluation of islet transplantation from non-heart beating donors,” American Journal of Transplantation, vol. 6, no. 10, pp. 2476–2482, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. B. J. Hering, R. Kandaswamy, J. D. Ansite et al., “Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes,” Journal of the American Medical Association, vol. 293, no. 7, pp. 830–835, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. B. J. Hering, R. Kandaswamy, J. V. Harmon et al., “Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody,” American Journal of Transplantation, vol. 4, no. 3, pp. 390–401, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. B. J. Hering, I. Matsumoto, T. Sawada et al., “Impact of two-layer pancreas preservation on islet isolation and transplantation,” Transplantation, vol. 74, no. 12, pp. 1813–1816, 2002. View at Google Scholar · View at Scopus
  10. S. Matsumoto, M. Takita, D. Chaussabel et al., “Improving efficacy of clinical islet transplantation with iodixanol based islet purification, thymoglobulin induction and blockage of IL-1-beta and TNF-alpha,” Cell Transplantation. In press.
  11. S. Matsumoto, T. Okitsu, Y. Iwanaga et al., “Insulin independence after living-donor distal pancreatectomy and islet allotransplantation,” Lancet, vol. 365, no. 9471, pp. 1642–1644, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Noguchi, M. Ueda, Y. Nakai et al., “Modified two-layer preservation method (M-Kyoto/PFC) improves islet yields in islet isolation,” American Journal of Transplantation, vol. 6, no. 3, pp. 496–504, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. H. Noguchi, M. F. Levy, N. Kobayashi, and S. Matsumoto, “Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution?” Cell Transplantation, vol. 18, no. 5-6, pp. 497–503, 2009. View at Google Scholar · View at Scopus
  14. H. Noguchi, “Pancreatic islet transplantation,” World Journal of Gastrointestinal Surgery, vol. 1, no. 1, pp. 16–20, 2009. View at Google Scholar
  15. H. Noguchi, T. Ikemoto, B. Naziruddin et al., “Iodixanol-controlled density gradient during islet purification improves recovery rate in human islet isolation,” Transplantation, vol. 87, no. 11, pp. 1629–1635, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. H. Noguchi, S. Matsumoto, N. Onaca et al., “Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function,” Human Gene Therapy, vol. 20, no. 1, pp. 73–85, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. H. Noguchi, B. Naziruddin, M. Shimoda et al., “A combined continuous density/osmolality gradient for supplemental purification of human islets,” Cell Medicine. In press.
  18. H. Noguchi, Y. Nakai, S. Matsumoto et al., “Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function,” American Journal of Transplantation, vol. 5, no. 8, pp. 1848–1855, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. H. Noguchi, Y. Nakai, M. Ueda et al., “Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor,” Diabetologia, vol. 50, no. 3, pp. 612–619, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. H. Noguchi, B. Naziruddin, A. Jackson et al., “Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation,” Transplantation, vol. 89, no. 1, pp. 47–54, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. H. Noguchi, “Cell-permeable peptide inhibitor of c-Jun NH2-terminal kinase for the treatment of diabetes,” Current Bioactive Compounds, vol. 6, no. 1, pp. 23–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Noguchi, M. Matsushita, T. Okitsu et al., “A new cell-permeable peptide allows successful allogeneic islet transplantation in mice,” Nature Medicine, vol. 10, no. 3, pp. 305–309, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. J. R. T. Lakey, G. L. Warnock, R. V. Rajotte et al., “Variables in organ donors that affect the recovery of human islets of Langerhans,” Transplantation, vol. 61, no. 7, pp. 1047–1053, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Brandhorst, B. J. Hering, H. Brandhorst, K. Federlin, and R. G. Bretzel, “Influence of donor data and organ procurement on human islet isolation,” Transplantation Proceedings, vol. 26, no. 2, pp. 592–593, 1994. View at Google Scholar · View at Scopus
  25. P. Fiedor, E. R. Goodman, R. S. Sung, J. Czerwiński, W. Rowiński, and M. A. Hardy, “The effect of clinical and biochemical donor parameters on pancreatic islet isolation yield from cadaveric organ donors,” Annals of Transplantation, vol. 1, no. 1, pp. 59–62, 1996. View at Google Scholar · View at Scopus
  26. Y. Zeng, M. A. Torre, T. Karrison, and J. R. Thistlethwaite, “The correlation between donor characteristics and the success of human islet isolation,” Transplantation, vol. 57, no. 6, pp. 954–958, 1994. View at Google Scholar · View at Scopus
  27. J. F. Markmann, S. Deng, N. M. Desai et al., “The use of non-heart-beating donors for isolated pancreatic islet transplantation,” Transplantation, vol. 75, no. 9, pp. 1423–1429, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. H. A. Clayton, S. M. Swift, J. M. Turner, R. F. L. James, and P. R. F. Bell, “Non-heart-beating organ donors: a potential source of islets for transplantation,” Transplantation, vol. 69, no. 10, pp. 2094–2098, 2000. View at Google Scholar · View at Scopus
  29. H. Nagata, S. Matsumoto, T. Okitsu et al., “Procurement of the human pancreas for pancreatic islet transplantation from marginal cadaver donors,” Transplantation, vol. 82, no. 3, pp. 327–331, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. M. Kato, K. Mizutani, R. Hattori et al., “In situ renal cooling for kidney transplantation from non-heart-beating donors,” Transplantation Proceedings, vol. 32, no. 7, pp. 1608–1610, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Yonekawa, S. Matsumoto, T. Okitsu et al., “Effective islet isolation method with extremely high islet yields from adult pigs,” Cell Transplantation, vol. 14, no. 10, pp. 757–762, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. J. J. O'Neil, J. P. Stegemann, D. T. Nicholson, K. A. Gagnon, B. A. Solomon, and C. J. P. Mullon, “The isolation and function of porcine islets from market weight pigs,” Cell Transplantation, vol. 10, no. 3, pp. 235–246, 2001. View at Google Scholar · View at Scopus
  33. C. Ricordi, P. E. Lacy, E. H. Finke, B. J. Olack, and D. W. Scharp, “Automated method for isolation of human pancreatic islets,” Diabetes, vol. 37, no. 4, pp. 413–420, 1988. View at Google Scholar · View at Scopus
  34. S. R. Munn, D. B. Kaufman, M. J. Field, A. B. Viste, and D. E. R. Sutherland, “Cold-storage preservation of the canine and rat pancreas prior to islet isolation,” Transplantation, vol. 47, no. 1, pp. 28–31, 1989. View at Google Scholar · View at Scopus
  35. H. Noguchi, M. Ueda, S. Hayashi et al., “Ductal injection of preservation solution increases islet yields in islet isolation and improves islet graft function,” Cell Transplantation, vol. 17, no. 1-2, pp. 69–81, 2008. View at Google Scholar · View at Scopus
  36. T. Sawada, I. Matsumoto, M. Nakano, N. Kirchhof, D. E. R. Sutherland, and B. J. Hering, “Improved islet yield and function with ductal injection of University of Wisconsin solution before pancreas preservation,” Transplantation, vol. 5, no. 12, pp. 1965–1969, 2003. View at Google Scholar · View at Scopus
  37. T. Tojimbara, W. N. Wicomb, R. Garcia-Kennedy et al., “Liver transplantation from non-heart beating donors in rats: influence of viscosity and temperature of initial flushing solutions on graft function,” Liver Transplantation and Surgery, vol. 3, no. 1, pp. 39–45, 1997. View at Google Scholar · View at Scopus
  38. G. S. Robertson, D. Chadwick, S. Thirdborough et al., “Human islet isolation—a prospective randomized comparison ofpancreatic vascular perfusion with hyperosmolar citrate or University ofWisconsin solution,” Transplantation, vol. 56, no. 3, pp. 550–553, 1993. View at Google Scholar
  39. H. H. Contractor, P. R. V. Johnson, D. R. Chadwick, G. S. M. Robertson, and N. J. M. London, “The effect of UW solution and its components on the collagenase digestion of human and porcine pancreas,” Cell Transplantation, vol. 4, no. 6, pp. 615–619, 1995. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Omasa, S. Hasegawa, T. Bando et al., “Application of ET-Kyoto solution in clinical lung transplantation,” Annals of Thoracic Surgery, vol. 77, no. 1, pp. 338–339, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Chen, T. Fukuse, S. Hasegawa et al., “Effective application of ET-Kyoto solution for clinical lung transplantation,” Transplantation Proceedings, vol. 36, no. 9, pp. 2812–2815, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. S. F. Wu, Y. Suzuki, A. K. Kitahara, H. Wada, and Y. Nishimura, “Skin flap storage with intracellular and extracellular solutions containing trehalose,” Annals of Plastic Surgery, vol. 43, no. 3, pp. 289–294, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Troisi, D. Meester, C. Van Den Broecke et al., “Functional and structural integrity of porcine pancreatic graftssubjected to a period of warm ischemia and cold preservation withhistidine-tryptophan-ketoglutarate (custodiol) or University of Wisconsinsolution,” Transplantation, vol. 75, no. 11, pp. 1793–1799, 2003. View at Google Scholar
  44. F. O. Belzer and J. H. Southard, “Organ preservation and transplantation,” Progress in Clinical and Biological Research, vol. 224, pp. 291–303, 1986. View at Google Scholar
  45. D. R. Chadwick, G. S. M. Robertson, H. H. Contractor et al., “Storage of pancreatic digest before islet purification: the influence of colloids and the sodium to potassium ratio in University of Wisconsin-based preservation solutions,” Transplantation, vol. 58, no. 1, pp. 99–104, 1994. View at Google Scholar
  46. S. Fujimoto, E. R. I. Mukai, Y. Hamamoto et al., “Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets,” Endocrinology, vol. 143, no. 1, pp. 213–221, 2002. View at Publisher · View at Google Scholar
  47. H. Noguchi, B. Naziruddin, N. Onaca et al., “Comparison of modified Celsior solution and M-Kyoto solution for pancreas preservation in human islet isolation,” Cell Transplantation, vol. 19, no. 6-7, pp. 751–758, 2010. View at Publisher · View at Google Scholar · View at PubMed
  48. H. J. Bretschneider, “Myocardial protection,” The Thoracic and Cardiovascular Surgeon, vol. 28, no. 5, pp. 295–302, 1980. View at Google Scholar
  49. J. Erhard, R. Lange, R. Scherer et al., “Comparison of histidine-tryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution for organ preservation in human liver transplantation. A prospective, randomized study,” Transplant International, vol. 7, no. 3, pp. 177–181, 1994. View at Google Scholar
  50. U. J. Hesse, R. Troisi, B. Jacobs et al., “Cold preservation of the porcine pancreas with histidine-tryptophan- ketoglutarate solution,” Transplantation, vol. 66, no. 9, pp. 1137–1141, 1998. View at Google Scholar
  51. U. Leonhardt, A. Tytko, B. Exner et al., “The effect of different solutions for organ preservation of immediate postischemic pancreatic function in vitro,” Transplantation, vol. 55, no. 1, pp. 11–14, 1993. View at Google Scholar · View at Scopus
  52. S. Potdar, S. Malek, B. Eghtesad et al., “Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation,” Clinical Transplantation, vol. 18, no. 6, pp. 661–665, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. M. J. Englesbe, A. Moyer, D. Y. Kim et al., “Early pancreas transplant outcomes with histidine-tryptophan-ketoglutarate preservation: a multicenter study,” Transplantation, vol. 82, no. 1, pp. 136–139, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. J. A. Fridell, A. Agarwal, M. L. Milgrom, W. C. Goggins, P. Murdock, and M. D. Pescovitz, “Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation,” Transplantation, vol. 77, no. 8, pp. 1304–1306, 2004. View at Google Scholar · View at Scopus
  55. H. Noguchi, M. Ueda, S. Hayashi et al., “Comparison of M-Kyoto solution and histidine-tryptophan-ketoglutarate solution with a trypsin inhibitor for pancreas preservation in islet transplantation,” Transplantation, vol. 84, no. 5, pp. 655–658, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  56. J. Caballero-Corbalán, H. Brandhorst, H. Malm et al., “Using HTK for prolonged pancreas preservation prior to human islet isolation,” The Journal of Surgical Research. In press.
  57. P. Menasché, J. L. Termignon, F. Pradier et al., “Experimental evaluation Celsior, a new heart preservation solution,” European Journal of Cardio-Thoracic Surgery, vol. 8, no. 4, pp. 207–213, 1994. View at Google Scholar · View at Scopus
  58. R. F. Roberts, G. P. Nishanian, J. N. Carey, Y. Sakamaki, V. A. Starnes, and M. L. Barr, “A comparison of the new preservation solution Celsior to Euro-Collins and University of Wisconsin solutions in lung reperfusion injury,” Transplantation, vol. 67, no. 1, pp. 152–155, 1999. View at Publisher · View at Google Scholar · View at Scopus
  59. A. Cavallari, U. Cillo, B. Nardo et al., “A multicenter pilotprospective study comparing Celsior and University of Wisconsin preservingsolutions for use in liver transplantation,” Liver Transplantation, vol. 9, no. 8, pp. 814–821, 2003. View at Google Scholar
  60. A. Faenza, F. Catena, B. Nardo et al., “Kidney preservationwith university of Wisconsin and Celsior solution: a prospective multicenterrandomized study,” Transplantation, vol. 72, no. 7, pp. 1274–1277, 2001. View at Google Scholar
  61. T. Hubert, V. Gmyr, L. Arnalsteen et al., “Influence of preservation solution on human islet isolation outcome,” Transplantation, vol. 83, no. 3, pp. 270–276, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. H. Noguchi, M. Ueda, S. Hayashi et al., “Comparison of trypsin inhibitors in preservation solution for islet isolation,” Cell Transplantation, vol. 18, no. 5-6, pp. 541–547, 2009. View at Google Scholar · View at Scopus
  63. H. Noguchi, B. Naziruddin, A. Jackson et al., “Comparison of ulinastatin, gabexatemesilate, and nafamostatmesilate in preservation solution for islet isolation,” Cell Transplantation. In press.
  64. J. R. T. Lakey, L. M. H. Helms, T. Kin et al., “Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia,” Transplantation, vol. 72, no. 4, pp. 565–570, 2001. View at Google Scholar · View at Scopus
  65. S. Aosasa, S. Ono, H. Mochizuki, H. Tsujimoto, C. Ueno, and A. Matsumoto, “Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor α production of monocytes,” Shock, vol. 15, no. 2, pp. 101–105, 2001. View at Google Scholar · View at Scopus
  66. S. Aosasa, S. Ono, S. Seki et al., “Inhibitory effect of protease inhibitor on endothelial cell activation,” Journal of Surgical Research, vol. 80, no. 2, pp. 182–187, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. K. Nakatani, S. Takeshita, H. Tsujimoto, Y. Kawamura, and I. Sekine, “Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury,” Journal of Leukocyte Biology, vol. 69, no. 2, pp. 241–247, 2001. View at Google Scholar · View at Scopus
  68. J. L. Sun, X. Q. Zhang, Z. G. Yu et al., “Effects of ulinastatin on postoperative systemic inflammatory response of recipients of rat small bowel transplantation,” Transplantation Proceedings, vol. 38, no. 6, pp. 1803–1804, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. X. Q. Zhang, J. L. Sun, Y. J. Chen, R. Ma, X. H. Fan, and J. Z. Sun, “Amelioration of ischemia-reperfusion injury of transplanted small intestine by ulinastatin: effects on accumulation and adhesion of neutrophil,” Transplantation Proceedings, vol. 37, no. 10, pp. 4464–4466, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. H. Brandhorst, A. Friberg, H. H. Andersson et al., “The importance of tryptic-like activity in purified enzyme blends for efficient islet isolation,” Transplantation, vol. 87, no. 3, pp. 370–375, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. H. Noguchi, M. F. Levy, N. Kobayashi, and S. Matsumoto, “Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution?” Cell Transplantation, vol. 18, no. 5-6, pp. 497–503, 2009. View at Google Scholar · View at Scopus
  72. T. Tsujimura, Y. Kuroda, T. Kin et al., “Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method,” Transplantation, vol. 74, no. 12, pp. 1687–1691, 2002. View at Google Scholar · View at Scopus
  73. C. Ricordi, C. Fraker, J. Szust et al., “Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution,” Transplantation, vol. 75, no. 9, pp. 1524–1527, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. B. J. Hering, R. Kandaswamy, J. V. Harmon et al., “Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody,” American Journal of Transplantation, vol. 4, no. 3, pp. 390–401, 2004. View at Publisher · View at Google Scholar · View at Scopus
  75. J. Caballero-Corbalán, T. Eich, T. Lundgren et al., “No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation,” Transplantation, vol. 84, no. 7, pp. 864–869, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. T. Kin, M. Mirbolooki, P. Salehi et al., “Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon,” Transplantation, vol. 82, no. 10, pp. 1286–1290, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  77. K. K. Papas, B. J. Hering, L. Gunther, M. J. Rappel, C. K. Colton, and E. S. Avgoustiniatos, “Pancreas oxygenation is limited during preservation with the two-layer method,” Transplantation Proceedings, vol. 37, no. 8, pp. 3501–3504, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus