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Mediators of Inflammation
Volume 2010, Article ID 201929, 14 pages
Review Article

Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

1Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, Spain
2Centro de Hemoterapia y Hemodonación de Castilla y León, 47007-Valladolid, Spain

Received 1 December 2009; Accepted 9 April 2010

Academic Editor: Andrew Parker

Copyright © 2010 Yolanda Alvarez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of , , and several cytokines including a robust IL-10 response. Zymosan activated B-binding activity, but inhibition of NF- B was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including , showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of , thus unraveling a functional cooperation between eicosanoid production and cytokine production.