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Mediators of Inflammation
Volume 2010, Article ID 437246, 16 pages
http://dx.doi.org/10.1155/2010/437246
Review Article

Toll-Like Receptors: Role in Dermatological Disease

1Immunology Research Group, University of Calgary, Calgary, AB, Canada T2N 4N1
2Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1
3Department of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1

Received 29 January 2010; Revised 27 April 2010; Accepted 1 July 2010

Academic Editor: Natalija Novak

Copyright © 2010 Aswin Hari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.