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Mediators of Inflammation
Volume 2010 (2010), Article ID 610418, 9 pages
Review Article

Ozone and Ozonated Oils in Skin Diseases: A Review

1Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Viale Aldo Moro 2, 53100 Siena, Italy
2Dipartimento di Scienze Biomediche, Università degli Studi di Siena Viale Aldo Moro 2, 53100 Siena, Italy
3Department of Food and Nutrition, Kyung Hee University, Seoul 130-761, Republic of Korea
4Dipartimento di Fisiologia, Università degli Studi di Siena, Viale Aldo Moro 2, 53100 Siena, Italy

Received 23 March 2010; Accepted 12 May 2010

Academic Editor: Philip W. Wertz

Copyright © 2010 V. Travagli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although orthodox medicine has provided a variety of topical anti-infective agents, some of them have become scarcely effective owing to antibiotic- and chemotherapeutic-resistant pathogens. For more than a century, ozone has been known to be an excellent disinfectant that nevertheless had to be used with caution for its oxidizing properties. Only during the last decade it has been learned how to tame its great reactivity by precisely dosing its concentration and permanently incorporating the gas into triglycerides where gaseous ozone chemically reacts with unsaturated substrates leading to therapeutically active ozonated derivatives. Today the stability and efficacy of the ozonated oils have been already demonstrated, but owing to a plethora of commercial products, the present paper aims to analyze these derivatives suggesting the strategy to obtain products with the best characteristics.