Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012, Article ID 381358, 9 pages
http://dx.doi.org/10.1155/2012/381358
Research Article

Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis

1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
2Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan
3Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan
4Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
5Research Center of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
6Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
7Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan

Received 13 September 2012; Revised 30 October 2012; Accepted 6 November 2012

Academic Editor: I-Ming Jou

Copyright © 2012 Ming-Yuan Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Uchino, R. Bellomo, D. Goldsmith, S. Bates, and C. Ronco, “An assessment of the RIFLE criteria for acute renal failure in hospitalized patients,” Critical Care Medicine, vol. 34, no. 7, pp. 1913–1917, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. G. M. Chertow, E. Burdick, M. Honour, J. V. Bonventre, and D. W. Bates, “Acute kidney injury, mortality, length of stay, and costs in hospitalized patients,” Journal of the American Society of Nephrology, vol. 16, no. 11, pp. 3365–3370, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Lassnigg, D. Schmidlin, M. Mouhieddine et al., “Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study,” Journal of the American Society of Nephrology, vol. 15, no. 6, pp. 1597–1605, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. W. Van Biesen, R. Vanholder, and N. Lameire, “Defining acute renal failure: RIFLE and beyond,” Clinical Journal of the American Society of Nephrology, vol. 1, no. 6, pp. 1314–1319, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. R. A. Star, “Treatment of acute renal failure,” Kidney International, vol. 54, no. 6, pp. 1817–1831, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. J. L. Koyner, V. S. Vaidya, M. R. Bennett et al., “Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury,” Clinical Journal of the American Society of Nephrology, vol. 5, no. 12, pp. 2154–2165, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Calandra and T. Roger, “Macrophage migration inhibitory factor: a regulator of innate immunity,” Nature Reviews Immunology, vol. 3, no. 10, pp. 791–800, 2003. View at Google Scholar · View at Scopus
  8. H. Y. Lan, “Role of macrophage migration inhibition factor in kidney disease,” Nephron, vol. 109, no. 3, pp. e79–e83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Leng, C. N. Metz, Y. Fang et al., “MIF signal transduction initiated by binding to CD74,” Journal of Experimental Medicine, vol. 197, no. 11, pp. 1467–1476, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Shi, L. Leng, T. Wang et al., “CD44 Is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex,” Immunity, vol. 25, no. 4, pp. 595–606, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Roger, J. David, M. P. Glauser, and T. Calandra, “MIF regulates innate immune responses through modulation of Toll-like receptor 4,” Nature, vol. 414, no. 6866, pp. 920–924, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Roger, C. Froidevaux, C. Martin, and T. Calandra, “Macrophage migration inhibitory factor (MIF) regulates host responses to endotoxin through modulation of toll-like receptor 4 (TLR4),” Journal of Endotoxin Research, vol. 9, no. 2, pp. 119–123, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. P. W. West, L. C. Parker, J. R. Ward, and I. Sabroe, “Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1,” Immunology, vol. 125, no. 1, pp. 101–110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. C. C. Chuang, Y. C. Chuang, W. T. Chang et al., “Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection,” BMC Immunology, vol. 11, article 50, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Y. Lan, N. Yang, D. J. Nikolic-Paterson et al., “Expression of macrophage migration inhibitory factor in human glomerulonephritis,” Kidney International, vol. 57, no. 2, pp. 499–509, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Y. Hoi, M. J. Hickey, P. Hall et al., “Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice,” Journal of Immunology, vol. 177, no. 8, pp. 5687–5696, 2006. View at Google Scholar · View at Scopus
  17. F. G. Brown, D. J. Nikolic-Paterson, P. A. Hill et al., “Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritis,” Journal of the American Society of Nephrology, vol. 13, supplement 1, pp. S7–S13, 2001. View at Google Scholar · View at Scopus
  18. F. G. Brown, D. J. Nikolic-Paterson, S. J. Chadban et al., “Urine macrophage migration inhibitory factor concentrations as a diagnostic tool in human renal allograft rejection,” Transplantation, vol. 71, no. 12, pp. 1777–1783, 2001. View at Google Scholar · View at Scopus
  19. H. Y. Lan, N. Yang, F. G. Brown et al., “Macrophage migration inhibitory factor expression in human renal allograft rejection,” Transplantation, vol. 66, no. 11, pp. 1465–1471, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Y. Lan, W. Mu, N. Yang et al., “De novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis,” American Journal of Pathology, vol. 149, no. 4, pp. 1119–1127, 1996. View at Google Scholar · View at Scopus
  21. A. Hoberman, M. Charron, R. W. Hickey, M. Baskin, D. H. Kearney, and E. R. Wald, “Imaging studies after a first febrile urinary tract infection in young children,” New England Journal of Medicine, vol. 348, no. 3, pp. 195–202, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. K. L. Meyer-Siegler, K. A. Iczkowski, and P. L. Vera, “Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine,” Journal of Urology, vol. 175, no. 4, pp. 1523–1528, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Otukesh, S. M. Fereshtehnejad, R. Hoseini et al., “Urine macrophage migration inhibitory factor (MIF) in children with urinary tract infection: a possible predictor of acute pyelonephritis,” Pediatric Nephrology, vol. 24, no. 1, pp. 105–111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Sevketoglu, A. Yilmaz, A. Gedikbasi et al., “Urinary macrophage migration inhibitory factor in children with urinary tract infection,” Pediatric Nephrology, vol. 25, no. 2, pp. 299–304, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Bellomo, C. Ronco, J. A. Kellum, R. L. Mehta, and P. Palevsky, “Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group,” Critical Care, vol. 8, no. 4, pp. R204–R212, 2004. View at Google Scholar · View at Scopus
  26. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Google Scholar · View at Scopus
  27. S. Goodacre, J. Turner, and J. Nicholl, “Prediction of mortality among emergency medical admissions,” Emergency Medicine Journal, vol. 23, no. 5, pp. 372–375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. K. J. Rhee, C. J. Fisher, and N. H. Willitis, “The rapid acute physiology score,” American Journal of Emergency Medicine, vol. 5, no. 4, pp. 278–282, 1987. View at Google Scholar · View at Scopus
  29. M. D. Sanchez-Niño, A. B. Sanz, P. Ihalmo et al., “The MIF receptor CD74 in diabetic podocyte injury,” Journal of the American Society of Nephrology, vol. 20, no. 2, pp. 353–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. J. N. Sheu, M. C. Chen, S. L. Cheng, I. C. Lee, S. M. Chen, and G. J. Tsay, “Urine interleukin-1β in children with acute pyelonephritis and renal scarring,” Nephrology, vol. 12, no. 5, pp. 487–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. W. K. Han, V. Bailly, R. Abichandani, R. Thadhani, and J. V. Bonventre, “Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury,” Kidney International, vol. 62, no. 1, pp. 237–244, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. O. Liangos, M. C. Perianayagam, V. S. Vaidya et al., “Urinary N-acetyl-β-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure,” Journal of the American Society of Nephrology, vol. 18, no. 3, pp. 904–912, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Bernhagen, T. Calandra, R. A. Mitchell et al., “MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia,” Nature, vol. 365, no. 6448, pp. 756–759, 1993. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Calandra, B. Echtenacher, D. Le Roy et al., “Protection from septic shock by neutralization of macrophage migration inhibitory factor,” Nature Medicine, vol. 6, no. 2, pp. 164–170, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Calandra, L. A. Spiegel, C. N. Metz, and R. Bucala, “Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 19, pp. 11383–11388, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Calandra, C. Froidevaux, C. Martin, and T. Roger, “Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis,” Journal of Infectious Diseases, vol. 187, supplement 2, pp. S385–S390, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. F. A. Bozza, R. N. Gomes, A. M. Japiassú et al., “Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis,” Shock, vol. 22, no. 4, pp. 309–313, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. C. C. Chuang, S. T. Wang, W. C. Chen, C. C. Chen, L. I. Hor, and Y. C. Chuang, “Increases in serum macrophage migration inhibitory factor in patients with severe sepsis predict early mortality,” Shock, vol. 27, no. 5, pp. 503–506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. C. A. Dinarello, “Interleukin-1β,” Critical Care Medicine, vol. 33, no. 12, pp. S460–S462, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Y. Lan, M. Bacher, N. Yang et al., “The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat,” Journal of Experimental Medicine, vol. 185, no. 8, pp. 1455–1465, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. K. L. Meyer-Siegler, K. A. Iczkowski, and P. L. Vera, “Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine,” Journal of Urology, vol. 175, no. 4, pp. 1523–1528, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Ichimura, J. V. Bonventre, V. Bailly et al., “Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury,” Journal of Biological Chemistry, vol. 273, no. 7, pp. 4135–4142, 1998. View at Publisher · View at Google Scholar · View at Scopus
  43. W. K. Han, S. S. Waikar, A. Johnson et al., “Urinary biomarkers in the early diagnosis of acute kidney injury,” Kidney International, vol. 73, no. 7, pp. 863–869, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. B. S. Kim, S. W. Lim, C. Li et al., “Ischemia-reperfusion injury activates innate immunity in rat kidneys,” Transplantation, vol. 79, no. 10, pp. 1370–1377, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. H. J. Anders, B. Banas, and D. Schlöndorff, “Signaling danger: toll-like receptors and their potential roles in kidney disease,” Journal of the American Society of Nephrology, vol. 15, no. 4, pp. 854–867, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Chassin, J. M. Goujon, S. Darche et al., “Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways,” Journal of Immunology, vol. 177, no. 7, pp. 4773–4784, 2006. View at Google Scholar · View at Scopus