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Mediators of Inflammation
Volume 2012, Article ID 503128, 6 pages
Review Article

PGD Synthase and PGD2 in Immune Resposne

1Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 627-870, Republic of Korea
2Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
3Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, M/C 719, Chicago, IL 60612, USA

Received 20 March 2012; Revised 3 May 2012; Accepted 3 May 2012

Academic Editor: Carlos Henrique Serezani

Copyright © 2012 Myungsoo Joo and Ruxana T. Sadikot. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


PGD2 is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2 to PGD2 by PGD synthases (PGDSs). PGD2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2 provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.